Copyright © 1998 by Institute of Pharmacology
Polish Academy of Sciences 		Pol. J. Pharmacol., 1998, 50, 449-452
ISSN 1230-6002
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PRELIMINARY COMMUNICATION
 OPPOSITE EFFECTS OF INHIBITORY AND EXCITATORY NEUROSTEROIDS ON [3H]DOPAMINE RELEASE FROM RAT NUCLEUS ACCUMBENS
 Lucylla Jaworska-Feil, Bogusława Budziszewska, Monika Leśkiewicz, Władysław Lasoń#
 Department of Endocrinology, Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, PL 31-343 Kraków, Poland

Opposite effects of inhibitory and excitatory neurosteroids on [3H]dopamine release from rat nucleus accumbens. L. JAWORSKA-FEIL, B. BUDZISZEWSKA, M. LEŚKIEWICZ, W. LASOŃ. Pol. J. Pharmacol., 1998, 50, 449-452.

Neurosteroids with GABAA receptor antagonistic properties increase K+-evoked [3H]dopamine release from rat nucleus accumbens slices, whereas neurosteroid positive modulators of GABAA exert an opposite effect.

Key words: neurosteroids, [3H]dopamine release, [3H]dopamine uptake, nucleus accumbens, rat
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