CONTENTS (PDF format)

Review - Prodrugs: A challenge for the drug development. Jolanta B. Zawilska, Jakub Wojcieszak, Agnieszka B. Olejniczak (p. 1) Abstract / Article (PDF format) New 8-aminoalkyl derivatives of purine-2,6-dione with arylalkyl, allyl or propynyl substituents in position 7, their 5-HT1A, 5-HT2A, and 5-HT7 receptor affinity and pharmacological evaluation. Grażyna Chłoń-Rzepa, Paweł Żmudzki, Grzegorz Satała, Beata Duszyńska, Anna Partyka, Dagmara Wróbel, Magdalena Jastrzębska-Więsek, Anna Wesołowska, Andrzej J. Bojarski, Maciej Pawłowski, Paweł Zajdel (p. 15) Abstract / Article (PDF format) Influence of aripiprazole and olanzapine on behavioral dysfunctions of adolescent rats exposed to stress in perinatal period. Piotr Ratajczak, Krzysztof Kus, Zofia Jarmuszkiewicz, Anna Woźniak, Michał Cichocki, Elżbieta Nowakowska (p. 30) Abstract / Article (PDF format) Effect of human interleukin-10 on the expression of nitric oxide synthases in the MPTP-based model of Parkinson's disease. Joanna Schwenkgrub, Ilona Joniec-Maciejak, Anna Sznejder-Pachołek, Adriana Wawer, Agnieszka Ciesielska, Krzysztof Bankiewicz, Anna Członkowska, Andrzej Członkowski (p. 44) Abstract / Article (PDF format) Effects of chronic flunitrazepam treatment schedule on therapy-induced sedation and motor impairment in mice. Sylwia Talarek, Jolanta Orzelska, Joanna Listos, Antonina Mazur, Sylwia Fidecka (p. 50) Abstract / Article (PDF format) Effects of n-3 polyunsaturated fatty acids on depressive symptoms, anxiety and emotional state in patients with acute myocardial infarction. Maciej Haberka, Katarzyna Mizia-Stec, Magdalena Mizia, Klaudia Gieszczyk, Artur Chmiel, Katarzyna Sitnik-Warchulska, Zbigniew Gąsior (p. 59) Abstract / Article (PDF format) Vasorelaxant and antihypertensive effects of ZCM298, a dihydropyridine derivative, are through inhibiting extracellular calcium influx. Li-Xin Zhang, Xin-lin Chen, Peng-bo Yang, San-Qi Zhang, Yong-Xiao Cao (p. 69) Abstract / Article (PDF format) Systemic synergism between codeine and morphine in three pain models in mice. Hugo F. Miranda, Viviana Noriega, Ramiro J. Zepeda, Fernando Sierralta, Juan C. Prieto (p. 80) Abstract / Article (PDF format) Progesterone therapy in women with epilepsy. Ewa Motta, Anna Golba, Zofia Ostrowska, Arkadiusz Steposz, Maciej Huc, Justyna Kotas-Rusnak, Jarogniew J. Łuszczki, Stanisław J. Czuczwar, Władysław Lasoń (p. 89) Abstract / Article (PDF format) Antioxidant agents and physiological responses in adult epileptic patients treated with lamotrigine. Elżbieta Płonka-Półtorak, Paweł Zagrodzki, Fergus Nicol, Jadwiga Kryczyk, Henryk Bartoń, Tuomas Westermarck, Pekka Kaipainen, Sakaewan Ounjaijean, Markus Kaski, Faik Atroshi (p. 99) Abstract / Article (PDF format) Assessing circadian rhythms during prolonged midazolam infusion in the pediatric intensive care unit (PICU) children. Agnieszka Bienert, Alicja Bartkowska-Śniatkowska, Paweł Wiczling, Jowita Rosada-Kurasińska, Małgorzata Grześkowiak, Czesław Żaba, Artur Teżyk, Anna Sokołowska, Roman Kaliszan, Edmund Grześkowiak (p. 107) Abstract / Article (PDF format) Influence of ezetimibe on ADMA-DDAH-NO pathway in rat liver subjected to partial ischemia followed by global reperfusion. Małgorzata Trocha, Anna Merwid-Ląd, Tomasz Sozański, Ewa Chlebda-Sieragowska, Andrzej Szuba, Piotr Dzięgiel, Małgorzata Pieśniewska, Lidia Fereniec-Gołębiewska, Joanna Kwiatkowska, Agnieszka Gomułkiewicz, Łucja Cwynar-Zając, Renata Brykner, Adam Szeląg (p. 122) Abstract / Article (PDF format) Enhanced anti-ulcer effect of pioglitazone on gastric ulcers in cirrhotic rats: The role of nitric oxide and IL-1beta. Leila Moezi, Reza Heidari, Zahra Amirghofran, Ali Akbar Nekooeian, Ahmad Monabati, Ahmad R. Dehpour (p. 134) Abstract / Article (PDF format) Evaluation of liver glycogen catabolism during hypercortisolism induced by the administration of dexamethasone in rats. Thauany M. Tavoni, Simoni Obici, Any de Castro R. Marques, Vania C. Minguetti-Câmara, Rui Curi, Roberto B. Bazotte (p. 144) Abstract / Article (PDF format) Mechanisms of [Ca2+]i elevation following P2X receptor activation in the guinea-pig small mesenteric artery myocytes. Khrystyna Yu. Sukhanova, Maksym I. Harhun, Vitali A. Bouryi, Dmitri V. Gordienko (p. 152) Abstract / Article (PDF format) Apigenin inhibits TGF-beta1 induced fibroblast-to-myofibroblast transition in human lung fibroblast populations. Katarzyna Anna Wójcik,Marta Skoda, Paulina Koczurkiewicz, Marek Sanak, Jarosław Czyż, Marta Michalik (p. 164) Abstract / Article (PDF format) Effects of acetylsalicylic acid on the levels of sulfane sulfur and non-protein sulfhydryl groups in mouse tissues. Anna Bilska-Wilkosz, Magdalena Ochenduszka, Małgorzata Iciek, Maria Sokołowska-Jeżewicz, Bogdan Wiliński, Marta Góralska, Zbigniew Srebro, Lidia Włodek (p. 173) Abstract / Article (PDF format) Effects of lipoic acid on spleen oxidative stress after LPS administration. Anna Gorąca, Halina Huk-Kolega, Paulina Kleniewska, Aleksandra Piechota-Polańczyk, Beata Skibska (p. 179) Abstract / Article (PDF format) Variability in CYP2C9 allele frequency: A pilot study of its predicted impact on warfarin response among healthy South and North Indians. Risha Nahar, Roumi Deb, Renu Saxena, Ratna Dua Puri, Ishwar Chander Verma (p. 187) Abstract / Article (PDF format) SHORT COMMUNICATIONS Cytisine inhibits the anticonvulsant activity of phenytoin and lamotrigine in mice. Piotr Tutka, Tomasz Mróz, Jerzy Bednarski, Andrzej Styk, Jaromir Ognik, Jerzy Mosiewicz, Jarogniew Łuszczki (p. 195) Abstract / Article (PDF format) Effect of cyclophosphamide and morin-5'-sulfonic acid sodium salt, alone or in combination, on ADMA/DDAH pathway in rats. Anna Merwid-Ląd, Małgorzata Trocha, Ewa Chlebda-Sieragowska, Tomasz Sozański, Jan Magdalan, Dorota Ksiądzyna, Andrzej Szuba, Maria Kopacz, Anna Kuźniar, Dorota Nowak, Małgorzata Pieśniewska, Lidia Fereniec-Gołębiewska, Adam Szeląg (p. 201) Abstract / Article (PDF format) Effect of metformin on selected parameters of hemostasis in fenofibrate-treated patients with impaired glucose tolerance. Robert Krysiak, Anna Gdula-Dymek, Bogusław Okopień (p. 208) Abstract / Article (PDF format) Influence of zinc hydroaspartate on the antiinflammatory and gastric activity of ketoprofen in rats. Magdalena Gaweł, Tadeusz Librowski, Anna Lipkowska (p. 214) Abstract / Article (PDF format) Neutrophil-infiltrated paw edema induced by mannose-binding Dioclea violacea lectin. Nylane Maria N. de Alencar, Mário Rogério L. Mota, Natália V. F. C. Rodrigues, Jorge Luiz Martins, Kyria S. do Nascimento, Ana Maria S. Assreuy, Benildo S. Cavada (p. 220) Abstract / Article (PDF format) Eplerenone promotes alternative activation in human monocyte-derived macrophages. Krzysztof Łabuzek, Sebastian Liber, Łukasz Bułdak, Grzegorz Machnik, Justyna Liber, Bogusław Okopień (p. 226) Abstract / Article (PDF format) Letter to the Editor - Can P-glycoprotein expression on malignant tumor tissues predict opioid transport at the blood-brain barrier in cancer patients? Bruno Mégarbane, Hisham Alhaddad (p. 235) PDF format Abstract of the Fifth Conference on PROGRESS IN EPILEPSY AND ANTIEPILETIC DRUGS (p. 239) PDF format

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Dr. Gert Schulze, M.D. (1941-2013). In memoriam. Helmut Coper, Krystyna Ossowska, Hans Rommelspacher (p. 267) Article (PDF format) Review - Vitamin D and the central nervous system. Małgorzata Wrzosek, Jacek Łukaszkiewicz, Michał Wrzosek, Andrzej Jakubczyk, Halina Matsumoto, Paweł Piątkiewicz, Maria Radziwoń-Zaleska, Marcin Wojnar, Grażyna Nowicka (p. 271) Abstract / Article (PDF format) Review - Fever development in neuroleptic malignant syndrome during treatment with olanzapine and clozapine. Anna Szota, Ewa Ogłodek, Aleksander Araszkiewicz (p. 279) Abstract / Article (PDF format) Review - Oxidative stress, polyunsaturated fatty acids-derived oxidation products and bisretinoids as potential inducers of CNS diseases: focus on age-related macular degeneration. Jerzy Z. Nowak (p. 288) Abstract / Article (PDF format) Review - Mydriasis model in rats as a simple system to evaluate alpha2-adrenergic activity of the imidazol(in)e compounds. Joanna Raczak-Gutknecht, Teresa Frąckowiak, Antoni Nasal, Roman Kaliszan (p. 305) Abstract / Article (PDF format) Review - Biochemical and pharmacological characterization of isatin and its derivatives: from structure to activity. Parvaneh Pakravan, Soheila Kashanian, Mohammad M. Khodaei, Frances J. Harding (p. 313) Abstract / Article (PDF format) Attenuation of stress-induced behavioral deficits by lithium administration via serotonin metabolism. Tahira Perveen, Saida Haider, Wajeeha Mumtaz, Faiza Razi, Saiqa Tabassum, Darakhshan J. Haleem (p. 336) Abstract / Article (PDF format) sigma Receptor antagonist attenuation of methamphetamine-induced neurotoxicity is correlated to body temperature modulation. Matthew J. Robson, Michael J. Seminerio, Christopher R. McCurdy, Andrew Coop, Rae R. Matsumoto (p. 343) Abstract / Article (PDF format) Nisoxetine blocks sodium currents and elicits spinal anesthesia in rats. Yuk-Man Leung, Chin-Chen Chu, Chang-Shin Kuo, Yu-Wen Chen, Jhi-Joung Wang (p. 350) Abstract / Article (PDF format) Antinociceptive synergy between diclofenac and morphine after local injection into the inflamed site. Jorge E. Torres-López, Elizabeth Carmona-Díaz, José L. Cortés-Penaloza, Crystell G. Guzmán-Priego, Héctor I. Rocha-González (p. 358) Abstract / Article (PDF format) Changes in the Egr1 and Arc expression in brain structures of pentylenetetrazole-kindled rats. Janusz Szyndler, Piotr Maciejak, Aleksandra Wisłowska-Stanek, Małgorzata Lehner, Adam Płaźnik (p. 368) Abstract / Article (PDF format) Effect of acute and chronic tianeptine on the action of classical antiepileptics in the mouse maximal electroshock model. Kinga K. Borowicz, Monika Banach, Barbara Piskorska, Stanisław J. Czuczwar (p. 379) Abstract / Article (PDF format) Effects of N-(morpholinomethyl)-p-isopropoxyphenyl- succinimide on the protective action of different classical antiepileptic drugs against maximal electroshock-induced tonic seizures in mice. Dorota Żółkowska, Mateusz Kominek, Magdalena Florek-Łuszczki, Sergey L. Kocharov, Jarogniew J. Łuszczki (p. 389) Abstract / Article (PDF format) Single centre 20 year survey of antiepileptic drug-induced hypersensitivity reactions. Barbara Błaszczyk, Monika Szpringer, Stanisław J. Czuczwar, Władysław Lasoń (p. 399) Abstract / Article (PDF format) Effects of sesquiterpene, flavonoid and coumarin types of compounds from Artemisia annua L. on production of mediators of angiogenesis. Xiaoxin X. Zhu, Lan Yang, Yujie J. Li, Dong Zhang, Ying Chen, Petra Kostecká, Eva Kmoníčková, Zdeněk Zídek (p. 410) Abstract / Article (PDF format) Changes in antioxidant capacity of blood due to mutual action of electromagnetic field (1800 MHz) and opioid drug (tramadol) in animal model of persistent inflammatory state. Paweł Bodera, Wanda Stankiewicz, Katarzyna Zawada, Bożena Antkowiak, Małgorzata Paluch, Jarosław Kieliszek, Bolesław Kalicki, Andrzej Bartosiński, Iwona Wawer (p. 421) Abstract / Article (PDF format) Lymphocyte-suppressing, endothelial-protective and systemic anti-inflammatory effects of metformin in fenofibrate-treated patients with impaired glucose tolerance. Robert Krysiak, Anna Gdula-Dymek, Bogusław Okopień (p. 429) Abstract / Article (PDF format) Anisomycin suppresses Jurkat T cell growth by the cell cycle-regulating proteins. Chunyan Yu, Feiyue Xing, Zhengle Tang, Christian Bronner, Xijian Lu, Jingfang Di, Shan Zeng, Jing Liu (p. 435) Abstract / Article (PDF format) In vivo effect of oracin on doxorubicin reduction, biodistribution and efficacy in Ehrlich tumor bearing mice. Veronika Hanušová, Pavel Tomšík, Lenka Kriesfalusyová, Alena Pakostová, Iva Boušová, Lenka Skálová (p. 445) Abstract / Article (PDF format) Synergistic anti-cancer activity of the combination of dihydroartemisinin and doxorubicin in breast cancer cells. Guo-Sheng Wu, Jin-Jian Lu, Jia-Jie Guo, Ming-Qing Huang, Li Gan, Xiu-Ping Chen, Yi-Tao Wang (p. 453) Abstract / Article (PDF format) In vivo and ex vivo responses of CLL cells to purine analogs combined with alkylating agent. Jolanta D. Żołnierczyk, Arleta Borowiak, Jerzy Z. Błoński, Barbara Cebula-Obrzut, Małgorzata Rogalińska, Aleksandra Kotkowska, Ewa Wawrzyniak, Piotr Smolewski, Tadeusz Robak, Zofia M. Kiliańska (p. 460) Abstract / Article (PDF format) Effects of vitamin D3 derivative - calcitriol on pharmacological reactivity of aortic rings in a rodent PCOS model. Gabriella Masszi, Agnes Novak, Robert Tarszabo, Eszter Maria Horvath, Anna Buday, Eva Ruisanchez, Anna-Maria Tokes, Levente Sara, Rita Benko, Gyorgy L. Nadasy, Csaba Revesz, Peter Hamar, Zoltán Benyó, Szabolcs Varbiro (p. 476) Abstract / Article (PDF format) Effects of single and repeated in vitro exposure of three forms of parabens, methyl-, butyl- and propylparabens on the proliferation and estradiol secretion in MCF-7 and MCF-10A cells. Anna Wróbel, Ewa Ł. Gregoraszczuk (p. 484) Abstract / Article (PDF format) Luminal melatonin stimulates pancreatic enzyme secretion via activation of serotonin-dependent nerves. Katarzyna Nawrot-Porąbka, Jolanta Jaworek, Anna Leja-Szpak, Joanna Szklarczyk, Stanisław J. Konturek, Russel J. Reiter (p. 494) Abstract / Article (PDF format) Benzylpenicillin inhibits the renal excretion of acyclovir by OAT1 and OAT3. Jianghao Ye, Qi Liu, Changyuan Wang, Qiang Meng, Huijun Sun, Jinyong Peng, Xiaochi Ma, Kexin Liu (p. 505) Abstract / Article (PDF format) SHORT COMMUNICATIONS Orexins/hypocretins stimulate accumulation of inositol phosphate in primary cultures of rat cortical neurons. Jolanta B. Zawilska, Anna Urbańska, Paulina Sokołowska (p. 513) Abstract / Article (PDF format) How to combine non-compartmental analysis with the population pharmacokinetics? A study of tobacco smoke's influence on the bioavailability of racemic citalopram in rats. Wojciech Jawień, Jagoda Majcherczyk, Maksymilian Kulza, Ewa Florek, Wojciech Piekoszewski (p. 517) Abstract / Article (PDF format) Down-regulation of thymic stromal lymphopoietin by curcumin. Phil-Dong Moon, Hyun-Ja Jeong, Hyung-Min Kim (p. 525) Abstract / Article (PDF format)

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Review - BDNF and VEGF in the pathogenesis of stress-induced affective diseases: An insight from experimental studies. Marta Nowacka, Ewa Obuchowicz (p. 535) Abstract / Article (PDF format) Review - Magnesium in depression. Anna Serefko, Aleksandra Szopa, Piotr Wlaź, Gabriel Nowak, Maria Radziwoń-Zaleska, Michał Skalski, Ewa Poleszak (p. 547) Abstract / Article (PDF format) Review - Hippocampus, hippocampal sclerosis and epilepsy. Krzysztof Sendrowski, Wojciech Sobaniec (p. 555) Abstract / Article (PDF format) Differential behavioral profile induced by the injection of dipotassium chlorazepate within brain areas that project to the nucleus accumbens septi. Luis H. Llano López, Fernando Caif, Miriam Fraile, Belén Tinnirello, Adriana I. Landa de Gargiulo, José V. Lafuente, Gustavo C. Baiardi , Pascual A. Gargiulo (p. 566) Abstract / Article (PDF format) Zinc deficiency alters responsiveness to antidepressant drugs in mice. Katarzyna Młyniec, Bogusława Budziszewska, Witold Reczyński, Urszula Doboszewska, Andrzej Pilc, Gabriel Nowak (p. 579) Abstract / Article (PDF format) Repeated central administration of selegiline attenuated morphine physical dependence in rat. Alireza Parvizpour, Mohammad Charkhpour, Bohlool Habibi-asl, Mobin Shakhsi, Majid Ghaderi, Kambiz Hassanzadeh (p. 593) Abstract / Article (PDF format) Peripheral antinociception and anti-edematogenic effect of a sulfated polysaccharide from Acanthophora muscoides. Ana L. G. Quinderé, Bruno P. Fontes, Edfranck de S. O. Vanderlei, Ismael N. L. de Queiroz, José A. G. Rodrigues, Ianna W. F. de Araújo, Roberta J. B. Jorge, Dalgimar B. de Menezes, Antonio A. R. e Silva, Hellíada V. Chaves, Janaina S. A. M. Evangelista, Mirna M. Bezerra, Norma M. B. Benevides (p. 600) Abstract / Article (PDF format) Negative influence of L-dopa on subjectively assessed sleep but not on nocturnal polysomnography in Parkinson's disease. Jakub M. Antczak, Maria J. Rakowicz, Marta Banach, Mirosława Derejko, Jakub Sienkiewicz, Urszula Zalewska, Małgorzata Więcławska, Tomasz Jakubczyk, Wojciech Jernajczyk (p. 614) Abstract / Article (PDF format) Effect of natalizumab on oxidative damage biomarkers in relapsing-remitting multiple sclerosis. Inmaculada Tasset, Carmen Bahamonde, Eduardo Agüera, Cristina Conde, Antonio H. Cruz, Aleyda Pérez-Herrera, Félix Gascón, Ana I. Giraldo, María C. Ruiz, Rafael Lillo, Fernando Sánchez-López, Isaac Túnez (p. 624) Abstract / Article (PDF format) Effects of diabetes and vascular occlusion on adenosine-induced relaxant response of rat common carotid artery. Miroslav Radenković, Marko Stojanović, Radmila Janković, Mirko Topalović, Milica Stojiljković (p. 632) Abstract / Article (PDF format) Melatonin-induced augmentation of collagen deposition in cultures of fibroblasts and myofibroblasts is blocked by luzindole - a melatonin membrane receptors inhibitor. Jacek Drobnik, Katarzyna Owczarek, Lucyna Piera, Dariusz Tosik, Sławomir Olczak, Joanna Ciosek, Elżbieta Hrabec (p. 642) Abstract / Article (PDF format) Study of the interaction of glutamatergic and nitrergic signalling in conditions of the experimental airways hyperreactivity. Martina Antošová, Anna Strapková (p. 650) Abstract / Article (PDF format) Modulatory effects of sesamol in dinitrochlorobenzene-induced inflammatory bowel disorder in albino rats. Phani Krishna Kondamudi, Hemalatha Kovelamudi, Geetha Mathew, Pawan G. Nayak, C. Mallikarjuna Rao, Rekha R. Shenoy (p. 658) Abstract / Article (PDF format) Long-term inhibition of intestinal lipase by orlistat improves release of gut hormones increasing satiety in obese women. Magdalena Olszanecka-Glinianowicz, Piotr Dąbrowski, Piotr Kocełak, Joanna Janowska, Mike Smertka, Krzysztof Jonderko, Jerzy Chudek (p. 666) Abstract / Article (PDF format) Inhibitory effect of antidepressants on B16F10 melanoma tumor growth. Beata Grygier, Beatriz Arteta, Marta Kubera, Agnieszka Basta-Kaim, Bogusława Budziszewska, Monika Leśkiewicz, Katarzyna Curzytek, Weronika Duda, Władysław Lasoń, Michael Maes (p. 672) Abstract / Article (PDF format) Cucurmosin induces the apoptosis of human pancreatic cancer CFPAC-1 cells by inactivating the PDGFR-beta signalling pathway. Jieming Xie, Congfei Wang, Baoming Zhang, Aiqin Yang, Qiang Yin, Heguang Huang, Minghuang Chen (p. 682) Abstract / Article (PDF format) Cytotoxic effect of lomefloxacin in culture of human epidermal melanocytes. Artur Beberok, Michał Otręba, Dorota Wrześniok, Ewa Buszman (p. 689) Abstract / Article (PDF format) Bisdemethoxycurcumin suppresses MCF-7 cells proliferation by inducing ROS accumulation and modulating senescence-related pathways. Ying-Bo Li, Jian-Li Gao, Zhang-Feng Zhong, Pui-Man Hoi, Simon Ming-Yuen Lee, Yi-Tao Wang (p. 700) Abstract / Article (PDF format) Involvement of spinal PKA/CREB signaling pathway in the development of bone cancer pain. Li-Hua Hang, Jian-Ping Yang, Dong-Hua Shao, Zheng Chen, Hong Wang (p. 710) Abstract / Article (PDF format) Evaluation of the anti-proliferative activity of three new pyrazole compounds in sensitive and resistant tumor cell lines. Maurizio Viale, Maria Anzaldi, Cinzia Aiello, Carla Fenoglio, Federica Albicini, Laura Emionite, Rosaria Gangemi, Alessandro Balbi (p. 717) Abstract / Article (PDF format) SHORT COMMUNICATIONS Effects of olanzapine and paroxetine on phospholipase D activity in the rat brain. Marek Krzystanek, Ewa Krzystanek, Henryk I. Trzeciak, Andrzej Małecki, Irena Krupka-Matuszczyk, Małgorzata Janas-Kozik, Janusz K. Rybakowski (p. 724) Abstract / Article (PDF format) Study of the protective effect of calcium channel blockers against neuronal damage induced by glutamate in cultured hippocampal neurons. Krzysztof Sendrowski, Małgorzata Rusak, Piotr Sobaniec, Elżbieta Iłendo, Milena Dąbrowska, Leszek Boćkowski, Alicja Koput, Wojciech Sobaniec (p. 730) Abstract / Article (PDF format) Metformin raises hydrogen sulfide tissue concentrations in various mouse organs. Bogdan Wiliński, Jerzy Wiliński, Eugeniusz Somogyi, Joanna Piotrowska, Włodzimierz Opoka (p. 737) Abstract / Article (PDF format) Effect of the nutritional supplement ALAnerv® on the serum PON1 activity in post-acute stroke patients. Bogdan N. Manolescu, Mihai Berteanu, Delia Cinteza (p. 743) Abstract / Article (PDF format) Expression of multiple Transient Receptor Potential channel genes in murine 3T3-L1 cell lines and adipose tissue. Mahendra Bishnoi, Kanthi Kiran Kondepudi, Aakriti Gupta, Aniket Karmase, Ravneet K. Boparai (p. 751) Abstract / Article (PDF format) Lymphocyte-suppressing action of simvastatin in patients with isolated hypertriglyceridemia. Robert Krysiak, Bogusław Okopień (p. 756) Abstract / Article (PDF format) Effect of anhydrosophoradiol-3-acetate of Calotropis gigantea (Linn.) flower as antitumoric agent against Ehrlich's ascites carcinoma in mice. Muhammad R. Habib, Muhammad R. Karim (p. 761) Abstract / Article (PDF format)

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Review - Serotonin discovery and stepwise disclosure of 5-HT receptor complexity over four decades. Part I. General background and discovery of serotonin as a basis for 5-HT receptor identification. Manfred Göthert (p. 771) Abstract / Article (PDF format) Review - Research advances in basic mechanisms of seizures and antiepileptic drug action. Władysław Lasoń, Małgorzata Chlebicka, Konrad Rejdak (p. 787) Abstract / Article (PDF format) Review - Female ovarian steroids in epilepsy: A cause or remedy. Mohammad N. Alam, Aakifa Ahmad, Fahad A. Al-Abbasi, Aftab Ahmad (p. 802) Abstract / Article (PDF format) Effects of serotonin (5-HT)1B receptor ligands on amphetamine-seeking behavior in rats. Joanna Miszkiel, Edmund Przegaliński (p. 813) Abstract / Article (PDF format) Synthesis and neuromodulatory effects of TRH-related peptides: inhibitory activity on catecholamine release in vitro. Luigi Brunetti, Annalisa Chiavaroli, Alessandra Cocco, Claudio Ferrante, Anna Ferrucci, Grazia Luisi, Giustino Orlando, Francesco Pinnen, Michele Vacca (p. 823) Abstract / Article (PDF format) Identification of Dmt-D-Lys-Phe-Phe-OH as a highly antinociceptive tetrapeptide metabolite of the opioid-neurotensin hybrid peptide PK20. Patrycja Kleczkowska, Engin Bojnik, Anna Leśniak, Piotr Kosson, Isabelle Van den Eynde, Steven Ballet, Sandor Benyhe, Dirk Tourwé, Andrzej W. Lipkowski (p. 836) Abstract / Article (PDF format) Different effects of postnatal caffeine treatment on two pentylenetetrazole-induced seizure models persist into adulthood. Jana D. Tchekalarova, Hana Kubová, Pavel Mareš (p. 847) Abstract / Article (PDF format) Differential effects of LY294002 and wortmannin on neurons and vascular endothelial cells in the rat retina. Kaori Ueda, Tsutomu Nakahara, Kaori Akanuma, Asami Mori, Kenji Sakamoto, Kunio Ishii (p. 854) Abstract / Article (PDF format) LPS-induced oxidative stress and inflammatory reaction in the rat striatum. Karolina Noworyta-Sokołowska, Anna Górska, Krystyna Gołembiowska (p. 863) Abstract / Article (PDF format) Can the antiplatelet effects of cangrelor be reliably studied in mice under in vivo and in vitro conditions using flow cytometry? Hassan Kassassir, Karolina Siewiera, Radosław Sychowski, Cezary Watała (p. 870) Abstract / Article (PDF format) Exendin-4 and GLP-1 decreases induced expression of ICAM-1, VCAM-1 and RAGE in human retinal pigment epithelial cells. Mariola Dorecka, Krzysztof Siemianowicz, Tomasz Francuz, Wojciech Garczorz, Agnieszka Chyra, Agnieszka Klych, Wanda Romaniuk (p. 884) Abstract / Article (PDF format) Disparate effects of anti-TNF-alpha therapies on measures of disease activity and mediators of endothelial damage in ankylosing spondylitis. Mariusz Korkosz, Jerzy Gąsowski, Andrzej Surdacki, Piotr Leszczyński, Katarzyna Pawlak-Buś, Sławomir Jeka, Maciej Siedlar, Tomasz Grodzicki (p. 891) Abstract / Article (PDF format) Influence of NADPH oxidase inhibition on oxidative stress parameters in rat hearts. Paulina Kleniewska, Marta Michalska, Anna Gorąca (p. 898) Abstract / Article (PDF format) Exposure to alcohol and tobacco smoke causes oxidative stress in rats. Ewa Ignatowicz, Anna Woźniak, Maksymilian Kulza, Monika Seńczuk-Przybyłowska, Francesco Cimino, Wojciech Piekoszewski, Marek Chuchracki, Ewa Florek (p. 906) Abstract / Article (PDF format) Exposure to ethanol and tobacco smoke in relation to level of PCNA antigen expression in pancreatic and hepatic rat cells. Ewa Wiśniewska, Anna Dylik, Maksymilian Kulza, Ewa Florek, Wojciech Piekoszewski, Monika Seńczuk-Przybyłowska, Andrzej Marszałek (p. 914) Abstract / Article (PDF format) Combination of omeprazole with GLP-1 agonist therapy improves insulin sensitivity and antioxidant activity in liver in type 1 diabetic mice. Vishal Patel, Amit Joharapurkar, Nirav Dhanesha, Samadhan Kshirsagar, Jaysukh Detroja, Kartikkumar Patel, Tejal Gandhi, Kirti Patel, Rajesh Bahekar, Mukul Jain (p. 927) Abstract / Article (PDF format) Metabolic effects of the HIV protease inhibitor - saquinavir in differentiating human preadipocytes. Monika Bociąga-Jasik, Anna Polus, Joanna Góralska, Urszula Czech, Anna Gruca, Agnieszka Sliwa, Aleksander Garlicki, Tomasz Mach, Aldona Dembińska-Kieć (p. 937) Abstract / Article (PDF format) Comparative evaluation of different doses of PPAR-gamma agonist alone and in combination with sulfasalazine in experimentally induced inflammatory bowel disease in rats. Prasad Byrav D.S., Bikash Medhi, Ajay Prakash, Amitava Chakrabarti, Kim Vaiphei, Krishan L. Khanduja (p. 951) Abstract / Article (PDF format) Effect of infliximab on metabolic disorders induced by Walker-256 tumor in rats. Daniele R. Miksza, Camila O. de Souza, Hely de Morais, Aline F. da Rocha, Gláucia R. Borba-Murad, Roberto B. Bazotte, Helenir M. de Souza (p. 960) Abstract / Article (PDF format) Anti-nephrolithic potential of resveratrol via inhibition of ROS, MCP-1, hyaluronan and osteopontin in vitro and in vivo. Sang Hyuk Hong, Hyo-Jung Lee, Eun Jung Sohn, Hyun-Suk Ko, Bum Sang Shim, Kyoo Seok Ahn, Sung-Hoon Kim (p. 970) Abstract / Article (PDF format) 1,2-Diazole prevents cisplatin-induced nephrotoxicity in experimental rats. Venugopal Vinod Prabhu, Narayanan Kannan, Chandrasekharan Guruvayoorappan (p. 980) Abstract / Article (PDF format) SHORT COMMUNICATIONS Involvement of NMDA and AMPA receptors in the antidepressant-like activity of antidepressant drugs in the forced swim test. Małgorzata Wolak, Agata Siwek, Bernadeta Szewczyk, Ewa Poleszak, Andrzej Pilc, Piotr Popik, Gabriel Nowak (p. 991) Abstract / Article (PDF format) Partial agonist efficacy of EMD386088, a 5-HT6 receptor ligand, in functional in vitro assays. Magdalena Jastrzębska-Więsek, Agata Siwek, Grzegorz Kazek, Barbara Nawieśniak, Anna Partyka, Monika Marcinkowska, Marcin Kołaczkowski, Anna Wesolowska (p. 998) Abstract / Article (PDF format) Dose-depending effect of intracerebroventricularly administered bradykinin on nociception in rats. Magdalena Bujalska-Zadrożny, Anna de Cordé, Krystyna Cegielska-Perun, Emilia Gąsińska, Helena Makulska-Nowak (p. 1006) Abstract / Article (PDF format) Enalapril enhances the anticonvulsant activity of lamotrigine in the test of maximal electroshock. Krzysztof Łukawski, Tomasz Jakubus, Agnieszka Janowska, Grzegorz Raszewski, Stanisław J. Czuczwar (p. 1012) Abstract / Article (PDF format) Are anti-inflammatory properties of lipoic acid associated with the formation of hydrogen sulfide? Magdalena Dudek, Anna Bilska-Wilkosz, Joanna Knutelska, Szczepan Mogilski, Marek Bednarski, Małgorzata Zygmunt, Małgorzata Iciek, Jacek Sapa, Dominik Bugajski, Barbara Filipek, Lidia Włodek (p. 1018) Abstract / Article (PDF format) Marsanidine and 7-Me-marsanidine, the new hypotensive imidazolines augment sodium and urine excretion in rats. Magdalena Wróblewska, Joanna Kasprzyk, Franciszek Sączewski, Anita Kornicka, Konrad Boblewski, Artur Lehmann, Apolonia Rybczyńska (p. 1025) Abstract / Article (PDF format) Tissue distribution of gold nanoparticles after single intravenous administration in mice. Marek Wojnicki, Magdalena Luty-Błocho, Marek Bednarski, Magdalena Dudek, Joanna Knutelska, Jacek Sapa, Małgorzata Zygmunt, Gabriel Nowak, Krzysztof Fitzner (p. 1033) Abstract / Article (PDF format)

CONTENTS (PDF format)

Review - Role of nitric oxide in the regulation of motor function. An overview of behavioral, biochemical and histological studies in animal models. Elżbieta Lorenc-Koci, Anna Czarnecka (p. 1043) Abstract / Article (PDF format) Review - Hyaluronan: Towards novel anti-cancer therapeutics. Michał S. Karbownik, Jerzy Z. Nowak (p. 1056) Abstract / Article (PDF format) Review - Biotechnology and genetic engineering in the new drug development. Part I. DNA technology and recombinant proteins. Agnieszka Stryjewska, Katarzyna Kiepura, Tadeusz Librowski, Stanisław Lochyński (p. 1075) Abstract / Article (PDF format) Review - Biotechnology and genetic engineering in the new drug development. Part II. Monoclonal antibodies, modern vaccines and gene therapy. Agnieszka Stryjewska, Katarzyna Kiepura, Tadeusz Librowski, Stanisław Lochyński (p. 1086) Abstract / Article (PDF format) Review - Biotechnology and genetic engineering in the new drug development. Part III. Biocatalysis, metabolic engineering and molecular modelling. Agnieszka Stryjewska, Katarzyna Kiepura, Tadeusz Librowski, Stanisław Lochyński (p. 1102) Abstract / Article (PDF format) MK-801, a NMDA receptor antagonist, increases phosphorylation of histone H3 in the rat medial prefrontal cortex. Marzena Maćkowiak, Rafał Guzik, Dorota Dudys, Ewelina Bator, Krzysztof Wędzony (p. 1112) Abstract / Article (PDF format) NMDA receptor activation antagonizes the NMDA antagonist-induced antianxiety effect in the elevated plus-maze test in mice. Ewa Poleszak, Anna Serefko, Aleksandra Szopa, Sylwia Wośko, Jarosław Dudka, Andrzej Wróbel, Tomasz Oniszczuk, Piotr Wlaź (p. 1124) Abstract / Article (PDF format) Effects of co-administration of the GABAB receptor agonist baclofen and a positive allosteric modulator of the GABAB receptor, CGP7930, on the development and expression of amphetamine-induced locomotor sensitization in rats. Laura N. Cedillo, Florencio Miranda (p. 1132) Abstract / Article (PDF format) Effect of risperidone on the fluoxetine-induced changes in extracellular dopamine, serotonin and noradrenaline in the rat frontal cortex. Katarzyna Kamińska, Krystyna Gołembiowska, Zofia Rogóż (p. 1144) Abstract / Article (PDF format) Effect of topiramate on hippocampus-dependent spatial memory in rats. Bogusława Pietrzak, Agnieszka Konopka, Jakub Wojcieszak (p. 1152) Abstract / Article (PDF format) Influence of chronic stress on brain corticosteroid receptors and HPA axis activity. Anna Gądek-Michalska, Jadwiga Spyrka, Paulina Rachwalska, Joanna Tadeusz, Jan Bugajski (p. 1163) Abstract / Article (PDF format) Conditioned rewarding effects of morphine and methadone in mice pre-exposed to cocaine. Małgorzata Hołuj, Adam Bisaga, Piotr Popik (p. 1176) Abstract / Article (PDF format) BDNF rs 6265 polymorphism and COMT rs 4680 polymorphism in deficit schizophrenia in Polish sample. Justyna Pełka-Wysiecka, Michał Wroński, Andrzej Jasiewicz, Anna Grzywacz, Piotr Tybura, Jolanta Kucharska-Mazur, Przemysław Bieńkowski, Jerzy Samochowiec (p. 1185) Abstract / Article (PDF format) Contribution of the mGluR7 receptor to antiparkinsonian-like effects in rats: a behavioral study with the selective agonist AMN082. Jolanta Konieczny, Tomasz Lenda (p. 1194) Abstract / Article (PDF format) Properties of 3-methyl-TIQ and 3-methyl-N-propargyl-TIQ for preventing MPTP-induced parkinsonism-like symptoms in mice. . Kanako Saitoh, Kenji Abe, Terumasa Chiba, Nobuyuki Katagiri, Toshiaki Saitoh, Yoshie Horiguchi, Hiroshi Nojima, Kyoji Taguchi (p. 1204) Abstract / Article (PDF format) Antioxidant potential of melatonin enhances the response to L-dopa in 1-methyl 4-phenyl 1,2,3,6- tetrahydropyridine-parkinsonian mice. Sawsan A. Zaitone, Lamiaa N. Hammad, Noha E. Farag (p. 1213) Abstract / Article (PDF format) Potential neuroprotective effect of ibuprofen, insights from the mice model of Parkinson’s disease. Maciej Swiątkiewicz, Małgorzata Zaremba, Ilona Joniec, Andrzej Członkowski, Iwona Kurkowska-Jastrzębska (p. 1227) Abstract / Article (PDF format) Inhibition of 2,4-dinitrofluorobenzene-induced contact hypersensitivity reaction by antidepressant drugs. Katarzyna Curzytek, Marta Kubera, Monika Majewska-Szczepanik, Marian Szczepanik, Katarzyna Marcińska, Włodzimierz Ptak, Weronika Duda, Monika Leśkiewicz, Agnieszka Basta-Kaim, Bogusława Budziszewska, Władysław Lasoń, Michael Maes (p. 1237) Abstract / Article (PDF format) Effect of antidepressant drugs on cytochrome P450 2C11 (CYP2C11) in rat liver. Jacek Wójcikowski, Anna Haduch, Władysława Anna Daniel (p. 1247) Abstract / Article (PDF format) Association between the HLA-B*15:02 allele and carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis in Han individuals of northeastern China. Xiao-Jing He, Ling-Yan Jian, Xiao-Lin He, Yan Wu, Yuan-Yuan Xu, Xiao-Jie Sun, Li-Yan Miao, Li-Mei Zhao (p. 1256) Abstract / Article (PDF format) Relationship of chemical structure and anti-inflammatory activity of dihydrocorynantheol and its analogues. Patrícia Pozzatti, Gustavo O. dos Reis, Danielle F. Pereira, Heros Horst, Leandro Espindola, Melina Heller, Gustavo A. Micke, Moacir G. Pizzolatti, Tânia S. Fröde (p. 1263) Abstract / Article (PDF format) Comparison of the effects of crocin, safranal and diclofenac on local inflammation and inflammatory pain responses induced by carrageenan in rats. Esmaeal Tamaddonfard, Amir-Abbas Farshid, Karim Eghdami, Farzad Samadi, Amir Erfanparast(p. 1272) Abstract / Article (PDF format) Simulation of early after-depolarisation in nonfailing human ventricular myocytes: Can this help cardiac safety pharmacology? Bernard Christophe (p. 1281) Abstract / Article (PDF format) Binding of new aminopropan-2-ol compounds to bovine serum albumin, alpha1-acid glycoprotein and rat serum using equilibrium dialysis and LC/MS/MS. Maria Walczak (p. 1294) Abstract / Article (PDF format) Levosimendan and its metabolite OR-1896 elicit KATP channel-dependent dilation in resistance arteries in vivo. Ildikó Gödény, Piero Pollesello, István Édes, Zoltán Papp, Zsolt Bagi (p. 1304) Abstract / Article (PDF format) Monocyte-suppressing effect of high-dose metformin in fenofibrate-treated patients with impaired glucose tolerance. Robert Krysiak, Anna Gdula-Dymek, Bogusław Okopień (p. 1311) Abstract / Article (PDF format) Effects of octane derivatives on activity of the volume-regulated anion channel in rat pancreatic beta-cells. Len Best, Peter D. Brown (p. 1317) Abstract / Article (PDF format) Glucocorticoid receptor regulates organic cation transporter 1 (OCT1, SLC22A1) expression via HNF4alpha upregulation in primary human hepatocytes. Alice Rulcova, Lucie Krausova, Tomas Smutny, Radim Vrzal, Zdenek Dvorak, Ramiro Jover, Petr Pavek (p. 1322) Abstract / Article (PDF format) Therapeutic efficacy of naringin on cyclosporine (A) induced nephrotoxicity in rats: Involvement of hemeoxygenase-1. Yamini Chandramohan, Chetenchery Somasundaram Parameswari (p. 1336) Abstract / Article (PDF format) Do effects of propranolol on the skeletal system depend on the estrogen status? Leszek Sliwiński, Joanna Folwarczna, Maria Pytlik, Urszula Cegieła, Barbara Nowińska, Hanna Trzeciak, Henryk I. Trzeciak (p. 1345) Abstract / Article (PDF format) Proteasome inhibitor inhibits proliferation and induces apoptosis in renal interstitial fibroblasts. Bingbing Zhu, Yuanmeng Jin, Lin Han, Hui Chen, Fang Zhong, Weiming Wang, Nan Chen (p. 1357) Abstract / Article (PDF format) Inhibition of Wnt/b-catenin signaling mediates ursolic acid-induced apoptosis in PC-3 prostate cancer cells. Ji-Hyuk Park, Hee-Young Kwon, Eun Jung Sohn, Kyung A. Kim, Bonglee Kim, Soo-Jin Jeong, Jun ho Song, Jin Suk Koo, Sung-Hoon Kim (p. 1366) Abstract / Article (PDF format) Effect of CYP2C9 and VKORC1 genetic variations on warfarin dose requirements in Indian patients. Sripriya Natarajan, Chandrashekhar K. Ponde, Rajesh M. Rajani, Farah Jijina, Roopkumar Gursahani, Pradnya P. Dhairyawan, Tester F. Ashavaid (p. 1375) Abstract / Article (PDF format) Pharmacokinetics of sunitinib in combination with fluoroquinolones in rabbit model. Edyta Szałek, Agnieszka Karbownik, Tomasz Grabowski, Katarzyna Sobańska, Anna Wolc, Edmund Grześkowiak (p. 1383) Abstract / Article (PDF format) Reductive metabolism of the sanguinarine iminium bond by rat liver preparations. Yong Wu, Zhao-Ying Liu, Yan Cao, Xiao-Jun Chen, Jian-Guo Zeng, Zhi-Liang Sun (p. 1391) Abstract / Article (PDF format) SHORT COMMUNICATIONS Effect of combined treatment with mirtazapine and risperidone on the MK-801-induced changes in the object recognition test in mice. Zofia Rogóż (p. 1401) Abstract / Article (PDF format) Ivabradine (a hyperpolarization activated cyclic nucleotide-gated channel blocker) elevates the threshold for maximal electroshock-induced tonic seizures in mice. Jarogniew J. Łuszczki, Andrzej Prystupa, Marta Andres-Mach, Ewa Marzęda, Magdalena Florek-Łuszczki (p. 1407) Abstract / Article (PDF format) Potential neurotoxic effect of ethylene glycol ethers mixtures. Bartosz Pomierny, Andrzej Starek, Weronika Krzyżanowska, Beata Starek-Swiechowicz, Irena Smaga, Lucyna Pomierny-Chamioło, Magdalena Regulska, Bogusława Budziszewska (p. 1415) Abstract / Article (PDF format) Effects of nifedipine on the pharmacokinetics of repaglinide in rats: Possible role of CYP3A4 and P-glycoprotein inhibition by nifedipine. Jin-Seok Choi, In Choi, Dong-Hyun Choi (p. 1422) Abstract / Article (PDF format) Gender-dependent activity of CYP3A is indirectly modified by GR in the noradrenergic system. Marta Kot, Grzegorz Kreiner, Piotr Chmielarz, Justyna Kuśmierczyk, Irena Nalepa, Władysława A. Daniel (p. 1431) Abstract / Article (PDF format)

CONTENTS (PDF format)

Overview - New trends in the neurobiology and pharmacology of affective disorders. Władysław Lasoń, Bogusława Budziszewska, Agnieszka Basta-Kaim, Marta Kubera, Michael Maes (p. 1441) Abstract / Article (PDF format) Review - Early maternal separation: a rodent model of depression and a prevailing human condition. Jerzy Vetulani (p. 1451) Abstract / Article (PDF format) Review - Impact of early-life stress on the medial prefrontal cortex functions - a search for the pathomechanisms of anxiety and mood disorders. Agnieszka Chocyk, Iwona Majcher-Maślanka, Dorota Dudys, Aleksandra Przyborowska, Krzysztof Wędzony (p. 1462) Abstract / Article (PDF format) Review - Potential roles of NCAM/PSA-NCAM proteins in depression and the mechanism of action of antidepressant drugs. Krzysztof Wędzony, Agnieszka Chocyk, Marzena Maćkowiak (p. 1471) Abstract / Article (PDF format) Review - Neurochemical modulation of stress-induced cognitive inflexibility in a rat model of an attentional set-shifting task. Agnieszka Nikiforuk, Piotr Popik (p. 1479) Abstract / Article (PDF format) Review - alpha1-Adrenergic receptor subtypes in the central nervous system: insights from genetically engineered mouse models. Irena Nalepa, Grzegorz Kreiner, Adam Bielawski, Katarzyna Rafa-Zabłocka, Adam Roman (p. 1489) Abstract / Article (PDF format) Review - Potential role of G protein-coupled receptor (GPCR) heterodimerization in neuropsychiatric disorders: A focus on depression. Kinga Szafran, Agata Faron-Górecka, Magdalena Kolasa, Maciej Kuśmider, Joanna Solich, Dariusz Żurawek, Marta Dziedzicka-Wasylewska (p. 1498) Abstract / Article (PDF format) Review - Is the mGlu5 receptor a possible target for new antidepressant drugs? Agnieszka Pałucha-Poniewiera, Joanna M. Wierońska, Piotr Brański, Grzegorz Burnat, Barbara Chruścicka, Andrzej Pilc (p. 1506) Abstract / Article (PDF format) Review - Zinc as a marker of affective disorders. Marcin Siwek, Bernadeta Szewczyk, Dominika Dudek, Krzysztof Styczeń, Magdalena Sowa-Kućma, Katarzyna Młyniec, Agata Siwek, Leszek Witkowski, Bartlomiej Pochwat, Gabriel Nowak (p. 1512) Abstract / Article (PDF format) Review - Role of brain cytochrome P450 (CYP2D) in the metabolism of monoaminergic neurotransmitters. Anna Haduch, Ewa Bromek, Władysława A. Daniel (p. 1519) Abstract / Article (PDF format) Review - Preclinical studies on comorbidity between depression and psychostimulant addiction. Małgorzata Filip, Małgorzata Frankowska, Joanna Jastrzębska, Karolina Wydra, Edmund Przegaliński (p. 1529) Abstract / Article (PDF format) Review - Combined treatment with atypical antipsychotics and antidepressants in treatment-resistant depression: Preclinical and clinical efficacy. Zofia Rogóż (p. 1535) Abstract / Article (PDF format) Review - Depression in Parkinson's disease. Krystyna Ossowska, Elżbieta Lorenc-Koci (p. 1545) Abstract / Article (PDF format) Review - Oxidative stress markers in affective disorders. Marcin Siwek, Magdalena Sowa-Kućma, Dominika Dudek, Krzysztof Styczeń, Bernadeta Szewczyk, Katarzyna Kotarska, Paulina Misztak, Agnieszka Pilc, Małgorzata Wolak, Gabriel Nowak (p. 1558) Abstract / Article (PDF format) Review - Glial degeneration as a model of depression. Maria Smiałowska, Bernadeta Szewczyk, Monika Woźniak, Anika Wawrzak-Wleciał, Helena Domin (p. 1572) Abstract / Article (PDF format) Review - Gender differences in genetic mouse models evaluated for depressive-like and antidepressant behavior. Grzegorz Kreiner, Piotr Chmielarz, Adam Roman, Irena Nalepa (p. 1580) Abstract / Article (PDF format) Review - Neuroendocrine link between stress, depression and diabetes. Jan Detka, Anna Kurek, Agnieszka Basta-Kaim, Marta Kubera, Władysław Lasoń, Bogusława Budziszewska (p. 1591) Abstract / Article (PDF format) Review - Mechanisms and pharmacology of diabetic neuropathy - experimental and clinical studies. Magdalena Zychowska, Ewelina Rojewska, Barbara Przewlocka, Joanna Mika (p. 1601) Abstract / Article (PDF format) Review - Neuronal and immunological basis of action of antidepressants in chronic pain - clinical and experimental studies. Joanna Mika, Magdalena Zychowska, Wioletta Makuch, Ewelina Rojewska, Barbara Przewlocka (p. 1611) Abstract / Article (PDF format) Review - Possible contribution of IGF-1 to depressive disorder. Ewa Szczęsny, Joanna Slusarczyk, Katarzyna Głombik, Bogusława Budziszewska, Marta Kubera, Władysław Lasoń, Agnieszka Basta-Kaim (p. 1622) Abstract / Article (PDF format) Review - Impact of endocrine-disrupting chemicals on neural development and the onset of neurological disorders. Małgorzata Kajta, Anna K. Wójtowicz (p. 1632) Abstract / Article (PDF format) Review - Involvement of prolactin and somatostatin in depression and the mechanism of action of antidepressant drugs. Agata Faron-Górecka, Maciej Kuśmider, Joanna Solich, Magdalena Kolasa, Kinga Szafran, Dariusz Żurawek, Paulina Pabian, Marta Dziedzicka-Wasylewska (p. 1640) Abstract / Article (PDF format) Review - Increased IL-6 trans-signaling in depression: Focus on the tryptophan catabolite pathway, melatonin and neuroprogression. George Anderson, Marta Kubera, Weronika Duda, Władysław Lasoń, Michael Berk, Michael Maes (p. 1647) Abstract / Article (PDF format) Review - Cytokines, prostaglandins and nitric oxide in the regulation of stress-response systems. Anna Gądek-Michalska, Joanna Tadeusz, Paulina Rachwalska, Jan Bugajski (p. 1655) Abstract / Article (PDF format) Review - Macrophages and depression - A misalliance or well-arranged marriage? Adam Roman, Grzegorz Kreiner, Irena Nalepa (p. 1663) Abstract / Article (PDF format) Review - Crosstalk between contact hypersensitivity reaction and antidepressant drugs. Katarzyna Curzytek, Marta Kubera, Marian Szczepanik, Agnieszka Basta-Kaim, Monika Leśkiewicz, Bogusława Budziszewska, Władysław Lasoń, Michael Maes (p. 1673) Abstract / Article (PDF format) Review - Ethanol withdrawal-induced depressive symptoms in animals and therapeutic potential of sigma1 receptor ligands. Grażyna Skuza (p. 1681) Abstract / Article (PDF format)