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OBITUARY - Associate Professor Maria Jolanta Mokrosz, Ph.D. (1949-2001). Edmund Przegaliński (p. 1) (PDF format) Propranolol prevents the development of venous thrombosis in rats by a platelet-dependent mechanism. Maciej Gruszecki, Roland Rółkowski, Robert Pawlak, Włodzimierz Buczko (p. 5) Abstract / Article (PDF format) Effect of phenobarbital and spironolactone treatment on the oxidative metabolism of antipyrine by rat liver microsomes. Tünde Szakács, Zsuzsa Veres, László Vereczkey (p. 11) Abstract / Article (PDF format) Aldrin-induced locomotor activity: possible involvement of the central GABAergic-cholinergic-dopaminergic interaction. Sk. Jamaluddin, Mrinal K. Poddar (p. 21) Abstract / Article (PDF format) Myotropic effects of new proctolin analogues modified in the position 5 of peptide chain in insects. Wioletta Szeszel-Fedorowicz, Grzegorz Rosiński, Jonathan Issberner, Richard Osborne, Joanna Śliwowska, Danuta Konopińska (p. 31) Abstract / Article (PDF format) SHORT COMMUNICATIONS Effect of glucocorticoid dexamethasone on cyclic AMP formation stimulated by pituitary adenylate cyclase-activating polypeptide (PACAP) in the cerebral cortex and hypothalamus of chick. Jolanta B. Zawilska, Jerzy Z. Nowak (p. 39) Abstract / Article (PDF format) NMDA antagonists inhibit the development of ethanol dependence in rats. Jolanta Kotlińska (p. 47) Abstract / Article (PDF format) PRELIMINARY COMMUNICATION Evaluation of interaction between valproate and baclofen in the formalin test in mice. Mirosław Czuczwar, Jacek Kiś, Mariusz Świąder, Waldemar A. Turski, Krzysztof Przesmycki (p. 51) Abstract / Article (PDF format) Papers of Fifth Conference on PROGRESS IN ETIOPATHOGENESIS OF SEIZURES (p. 57) (PDF format) Neurochemical and pharmacological aspects of cocaine-induced seizures. Władysław Lasoń (p. 57) Abstract / Article (PDF format) Effect of antihormones in amygdala-kindled seizures in rats. Kinga K. Borowicz (p. 61) Abstract / Article (PDF format) Felbamate, gabapentin and topiramate as adjuvant antiepileptic drugs in experimental models of epilepsy. Stanisław J. Czuczwar, Krzysztof Przesmycki (p. 65) Abstract / Article (PDF format) Effect of adenosine receptor agonists on neurodegenerative and convulsive activity of mitochondrial toxin, 3-nitropropionic acid. Beata Zuchora, Ewa M. Urbańska (p. 69) Abstract / Article (PDF format) Brain tolerance and preconditioning. Robert Rejdak, Konrad Rejdak, Maria Sieklucka-Dziuba, Zbigniew Stelmasiak, Paweł Grieb (p. 73) Abstract / Article (PDF format) Previous prolonged clonic seizures diminish antiepileptic activity of valproate against pentetrazol-evoked convulsions. Grzegorz Haberek, Tomasz Tomczyk, Ewa M. Urbańska (p. 81) Abstract / Article (PDF format) Effect of adenosine A1 and A2 receptor stimulation on hypoxia-induced convulsions in adult mice. Witold Zgodziński, Andrzej Rubaj, Zdzisław Kleinrok, Maria Sieklucka-Dziuba (p. 83) Abstract / Article (PDF format) Influence of chronic treatment with H1 receptor antagonists on the anticonvulsant activity of antiepileptic drugs. Mariusz Świąder, Katarzyna Chwalczuk, Marian Wielosz, Stanisław J. Czuczwar (p. 93) Abstract / Article (PDF format)

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Interaction of GYKI 52466, a selective non-competitive antagonist of AMPA/kainate receptors, with conventional antiepileptic drugs in amygdala-kindled seizures in rats. Kinga K. Borowicz, Andrzej M. Duda, Zdzisław Kleinrok, Stanisław J. Czuczwar (p. 101) Abstract / Article (PDF format) Neonatal treatment with 5,7-dihydroxytryptamine induces decrease in alcohol drinking in adult animals. Maria Jessa, Pawel Krząścik, Wojciech Kostowski (p. 109) Abstract / Article (PDF format) Influence of clonazepam and carbamazepine on alcohol withdrawal syndrome, preference and development of tolerance to ethanol in rats. Jarosław S. Strzelec, Elżbieta Czarnecka (p. 117) Abstract / Article (PDF format) Increase in NAD but not ATP and GTP concentrations in rat liver by dehydroepiandrosterone feeding. Julian Świerczyński, Ewa Słomińska, Ryszard T. Smoleński, Doris Mayer (p. 125) Abstract / Article (PDF format) Antianaphylactic and antiasthmatic properties of new piperazinyl 7-(beta-hydroxypropyl)-theophylline derivatives in guinea pigs. Ryszard Czarnecki, Tadeusz Librowski, Maciej Pawłowski (p. 131) Abstract / Article (PDF format) SHORT COMMUNICATIONS Effect of intraportal verapamil infusion on hepatic ischemia-reperfusion injury. Okan Erdogan, Sait Yíldíz, Abdulkadir Başaran, Alper Demirbaş, Akin Yeşilkaya (p. 137) Abstract / Article (PDF format) DNA-binding properties and cytotoxicity of extended aromatic bisamidines in breast cancer MCF-7 cells. Krzysztof Bielawski, Sławomir Wołczyński, Anna Bielawska (p. 143) Abstract / Article (PDF format) Opposite effects of mast cell degranulation by compound 48/80 on peritoneal inflammation in Swiss and CBA mice. Elżbieta Stankiewicz, Ewa Wypasek, Barbara Plytycz (p. 149) Abstract / Article (PDF format) Abstracts of the TENTH DAYS of NEUROPSYCHOPHARMACOLOGY (p. 165) Lectures / Oral presentations (PDF format)

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REVIEW - Drug addiction. Part I. Psychoactive substances in the past and presence. Jerzy Vetulani (p. 201) Abstract / Article (PDF format) REVIEW - Biosynthesis and biological properties of compounds containing highly reactive, reduced sulfane sulfur. Małgorzata Iciek, Lidia Włodek (p. 215) Abstract / Article (PDF format) Reversal of stress-induced memory changes by moclobemide: the role of neurotransmitters. Elżbieta Nowakowska, Alfons Chodera, Krzysztof Kus, Przemysław Nowak, Ryszard Szkilnik (p. 227) Abstract / Article (PDF format) Examination of the influence of 3,5-DHPG on behavioral activity of angiotensin II. Zdzisław Hoły, Konstanty Wiśniewski (p. 235) Abstract / Article (PDF format) AIDA influences behavior in rats pretreated with baclofen. Halina Car, Agnieszka Nadlewska, Robert Oksztel, Konstanty Wiśniewski (p. 245) Abstract / Article (PDF format) Influence of doxepin used in preemptive analgesia on the nociception in the perioperative period. Experimental and clinical study. Jerzy Wordliczek, Marcin Banach, Magdalena Dorazil, Barbara Przewłocka (p. 253) Abstract / Article (PDF format) Behavioral changes in the course of chronic renal insufficiency in rats. Joanna Topczewska-Bruns, Anna Tankiewicz, Dariusz Pawlak, Włodzimierz Buczko (p. 263) Abstract / Article (PDF format) Ischemic and reperfusive release of the endogenous purines and its influence on the myocardial viability during beta-adrenergic blockade. Krzysztof Żmudka, Jarosław Zalewski, Jacek Dubiel, Grzegorz Gajos, Jacek Legutko, Dariusz Dudek, Jarosław Trębacz, Artur Kocurek, Tadeusz Przewłocki, Piotr Pieniążek, Wilem Flameng, Hilaire De Geest (p. 271) Abstract / Article (PDF format) SHORT COMMUNICATION L-proline analogues of anthraquinone-2-carboxylic acid: cytotoxic activity in breast cancer MCF-7 cells and inhibitory activity against topoisomerase I and II. Anna Bielawska, Katarzyna Kosk, Krzysztof Bielawski (p. 283) Abstract / Article (PDF format) PRELIMINARY COMMUNICATION Lack of a modulatory effect of imipramine on glucocorticoid-induced suppression of interferon-gamma and interleukin-10 production in vitro. Marta Kubera, Gunter Kenis, Bogusława Budziszewska, Eugcne Bosmans, Simone Scharpe, Agnieszka Basta-Kaim, Michael Maes (p. 289) Abstract / Article (PDF format)

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OBITUARY - Associate Professor, Maria Bijak, Ph.D. (1957–2001). Edmund Przegaliński, Władysław Lasoń (p. 299) (PDF format) REVIEW - Drug addiction. Part II. Neurobiology of addiction. Jerzy Vetulani (p. 303) Abstract / Article (PDF format) Amphetamine-induced enhancement of neostriatal in vivo microdialysate dopamine content in rats, quinpirole-primed as neonates. Przemysław Nowak, Ryszard Brus, Richard M. Kostrzewa (p. 319) Abstract / Article (PDF format) NMDA receptor antagonists change behavioral activity of rats treated with (S)-4CPG. Halina Car, Robert Oksztel, Agnieszka Nadlewska, Konstanty Wiśniewski (p. 331) Abstract / Article (PDF format) Effect of cyclooxygenase and NO synthase inhibitors on antinociceptive action of acetaminophen. Magdalena Bujalska, Witold S. Gumułka (p. 341) Abstract / Article (PDF format) Effects of antidepressant drugs on the activity of cytochrome P-450 measured by caffeine oxidation in rat liver microsomes. Władysława A. Daniel, Maciej Syrek, Zbigniew Ryłko, Jacek Wójcikowski (p. 351) Abstract / Article (PDF format) Synthesis, 5-HT1A and 5-HT2A receptor activity of new 1-phenylpiperazinylpropyl derivatives with arylalkyl substituents in position 7 of purine-2,6-dione. Maciej Pawłowski, Beata Duszyńska, Anna Szaro, Ewa Tatarczyńska, Aleksandra Kłodzińska, Ewa Chojnacka-Wójcik (p. 359) Abstract / Article (PDF format) Substitution mode of the amide fragment in some new N-{omega-[4-(2-methoxyphenyl)piperazin-1-yl]alkyl}pyrid-2(1H)-ones and their 5-HT1A/5-HT2A activity. Maria H. Paluchowska, Ryszard Bugno, Sijka Charakchieva-Minol, Andrzej J. Bojarski, Anna Wesołowska (p. 369) Abstract / Article (PDF format) Immunotropic activity of vratizolin (ITCL, Denotivir). Zdzisław Machoń, Zbigniew Wieczorek, Michał Zimecki (p. 377) Abstract / Article (PDF format) SHORT COMMUNICATIONS Rapid down-regulation of GABA-A receptors after pretreatment of mice with progesterone. Agnieszka I. Członkowska, Pawel Krząścik, Halina Sienkiewicz-Jarosz, Marek Siemiątkowski, Janusz Szyndler, Piotr Maciejak, Andrzej Bidziński, Adam Płaźnik (p. 385) Abstract / Article (PDF format) Effects of histamine on phosphoinositide metabolism in chick cerebral cortex. Jolanta B. Zawilska, Agata Woldan-Tambor, Katarzyna Kuba, Jerzy Z. Nowak (p. 389) Abstract / Article (PDF format) Arylpiperazine derivatives of 3-propyl-beta-tetralonohydantoin as new 5-HT1A and 5-HT2A receptor ligands. Hanna Byrtus, Maciej Pawłowski, Beata Duszyńska, Anna Wesołowska, Ewa Chojnacka-Wójcik, Andrzej J. Bojarski (p. 395) Abstract / Article (PDF format) PRELIMINARY COMMUNICATION Effect of physiological and pharmacologically induced thymus involution on the immunoreactivity in C57BL mice. Agnieszka Basta-Kaim, Marta Kubera, Bogusława Budziszewska, Adam Roman, Anna Skowron-Cendrzak (p. 403) Abstract / Article (PDF format)

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OBITUARY - Christine Heim, MD (1949–2001). Jerzy Maj (p. 413) (PDF format) REVIEW - Drug addiction. Part III. Pharmacotherapy of addiction. Jerzy Vetulani (p. 415) Abstract / Article (PDF format) Behavioral alterations after unilateral 6-hydroxydopamine lesions of the striatum. Effect of alpha-tocopherol. Christine Heim, Wacław Kolasiewicz, Tino Kurz, Karl-Heinz Sontag (p. 435) Abstract / Article (PDF format) Serotonin1B receptor ligands in the nucleus accumbens shell do not affect the discriminative stimulus effects of amphetamine in rats. Małgorzata Filip, Ewa Nowak, Leokadia Baran, Edmund Przegaliński (p. 449) Abstract / Article (PDF format) Implication of the nucleus accumbens shell, but not core, in the acute and sensitizing effects of cocaine in rats. Małgorzata Filip, Joanna Siwanowicz (p. 459) Abstract / Article (PDF format) Glucocorticoids modulate behavioral effects induced by dopaminergic agonists in rats. Grażyna Ossowska, Andrzej Wróbel, Tomasz Łupina (p. 467) Abstract / Article (PDF format) Role of serotonergic and noradrenergic systems in a model of visceral pain. Iwona Korzeniewska-Rybicka, Adam Płaźnik (p. 475) Abstract / Article (PDF format) Developmental changes in the modulation of cyclic AMP accumulation by activation of metabotropic glutamate receptors. Agnieszka Pałucha, Piotr Brański, Bernadeta Kroczka, Joanna Wierońska, Andrzej Pilc (p. 481) Abstract / Article (PDF format) Effects of indomethacin on hemodynamic parameters after intravenous administration of propranolol and enalaprilat in rabbits. Jacek Kasznicki, Anna Wiktorowska-Owczarek (p. 487) Abstract / Article (PDF format) Differential patterns of cyclosporine A-induced inhibition of humoral and cellular immune responses to sheep erythrocytes in mice. Michał Zimecki, Zbigniew Wieczorek (p. 495) Abstract / Article (PDF format) 2-H- and 2-acyl-9-{omega-[4-(2-methoxyphenyl)piperazinyl]-alkyl}-1,2,3,4-tetrahydro-beta-carbolines as ligands of 5-HT1A and 5-HT2A receptors. Jan Boksa, Maria J. Mokrosz, Sijka Charakchieva-Minol, Ewa Tatarczyńska, Aleksandra Kłodzińska, Anna Wesołowska, Stanisław Misztal (p. 501) Abstract / Article (PDF format) SHORT COMMUNICATIONS Locomotor hypoactivity and motor disturbances – behavioral effects induced by intracerebellar microinjections of dopaminergic DA-D2/D3 receptor agonists. Waclaw Kolasiewicz, Jerzy Maj (p. 509) Abstract / Article (PDF format) Effects of anxiolytic drugs on some behavioral consequences in olfactory bulbectomized rats. Joanna M. Wierońska, Mariusz Papp, Andrzej Pilc (p. 517) Abstract / Article (PDF format) PRELIMINARY COMMUNICATIONS Isobolographic analysis of interaction between vigabatrin and baclofen in the formalin test in mice. Mirosław Czuczwar, Jacek Kiś, Andrzej Potasiński, Waldemar A. Turski, Krzysztof Przesmycki (p. 527) Abstract / Article (PDF format) Nociceptive changes in rats after prenatal exposure to valproic acid. Tomasz Schneider, Dominika Łabuz, Ryszard Przewłocki (p. 531) Abstract / Article (PDF format) Comparative investigations of hydroxyamine carane derivative and its R,S-diastereoisomers with strong local anesthetic activity. Tadeusz Librowski, Ryszard Czarnecki, Stanisław Lochyński, Bożena Frąckowiak, Marta Pasenkiewicz-Gierula, Jacek Grochowski, Paweł Serda (p. 535) Abstract / Article (PDF format) Immunoreactivity in kainate model of epilepsy. Marta Kubera, Bogusława Budziszewska, Agnieszka Basta-Kaim, Alena Zajicova, Vladimir Holan, Władysław Lasoń (p. 541) Abstract / Article (PDF format) Repeated treatment with SA4503, a selective sigma1 receptor agonist, up-regulates alpha1-adrenergic system. A behavioral study. Grażyna Skuza, Wacław Kolasiewicz (p. 547) Abstract / Article (PDF format)

OBITUARY - Professor Stanisław Kohlmünzer, Ph.D. Honoris Causa (1919–2001). Wanda Kisiel (p. 555) (PDF format) REVIEW - Resveratrol, a natural chemopreventive agent against degenerative diseases. Ewa Ignatowicz, Wanda Baer-Dubowska (p. 557) Abstract / Article (PDF format) Repeated imipramine treatment enhances the 7-OH-DPAT-induced hyperactivity in rats: the role of dopamine D2 and D3 receptors. Zofia Rogóż, Grażyna Skuza (p. 571) Abstract / Article (PDF format) Does combined treatment with novel antidepressants and a dopamine D3 receptor agonist reproduce cocaine discrimination in rats? Małgorzata Filip, Iwona Papla (p. 577) Abstract / Article (PDF format) Effect of NOS inhibitor on forced swim test and neurotransmitters turnover in the mouse brain. Beata Karolewicz, Ian A. Paul, Lucyna Antkiewicz-Michaluk (p. 587) Abstract / Article (PDF format) NG-nitro-L-arginine and its methyl ester inhibit brain synthesis of kynurenic acid possibly via nitric oxide-independent mechanism. Piotr Luchowski, Tomasz Kocki, Ewa M. Urbańska (p. 597) Abstract / Article (PDF format) Pharmacometric analysis of alpha1-adrenoceptor function in rat tail artery pretreated with lipopolysaccharides. Grzegorz Grześk, Leszek Szadujkis-Szadurski (p. 605) Abstract / Article (PDF format) Effects of phenothiazine neuroleptics on the rate of caffeine demethylation and hydroxylation in the rat liver. Władysława A. Daniel, Maciej Syrek, Zbigniew Ryłko, Marta Kot (p. 615) Abstract / Article (PDF format) In vitro-in vivo correlation of the pharmacokinetics of vinpocetine. Tünde Szakács, Zsuzsa Veres, László Vereczkey (p. 623) Abstract / Article (PDF format) NADPH-induced oxidative damage of rat liver microsomes: protective role of chlorpromazine and trifluoperazine. Atanu K. Khatua, Maitree Bhattacharyya (p. 629) Abstract / Article (PDF format) SHORT COMMUNICATIONS Repeated imipramine administration enhances the effects of NMDA receptor ligands on synchronous activity in rat frontal cortex in vitro. Bartosz Bobula, Krzysztof Tokarski, Grzegorz Hess (p. 635) Abstract / Article (PDF format) Rise in zinc affinity for the NMDA receptor evoked by chronic imipramine is species-specific. Bernadeta Szewczyk, Renata Kata, Gabriel Nowak (p. 641) Abstract / Article (PDF format) Aorta response to secretin in intact and diabetic rats. Róża J. Wiśniewska, Ewa M. Sitniewska (p. 647) Abstract / Article (PDF format) Significance of toxic interactions in medicolegal evidence. Complex fatal poisoning with drugs of abuse in the material of the Chair of Forensic Medicine, Collegium Medicum, Jagiellonian University in Kraków. Małgorzata Kłys, Beata Bystrowska, Beata Bujak-Giżycka, Gabriel Nowak (p. 653) Abstract / Article (PDF format) PRELIMINARY COMMUNICATIONS Changes in the expression of metabotropic glutamate receptor 5 (mGluR5) in the rat hippocampus in an animal model of depression. Joanna M. Wierońska, Piotr Brański, Bernadeta Szewczyk, Agnieszka Pałucha, Mariusz Papp, Piotr Gruca, Elżbieta Moryl, Andrzej Pilc (p. 659) Abstract / Article (PDF format) Effect of repeated treatment with reboxetine on the central alpha1-adrenergic system. Zofia Rogóż, Wacław Kolasiewicz (p. 663) Abstract / Article (PDF format) Opposite effects of olanzapine and haloperidol in rat ultrasonic vocalization test. Marek Siemiątkowski, Piotr Maciejak, Halina Sienkiewicz-Jarosz, Agnieszka I. Członkowska, Janusz Szyndler, Alicja Gryczyńska, Adam Płaźnik (p. 669) Abstract / Article (PDF format) Immunohistochemical evidence for localization of NMDAR1 receptor subunit on dopaminergic neurons of the rat substantia nigra, pars compacta. Krzysztof Wędzony, Klaudia Czepiel, Katarzyna Fijał (p. 675) Abstract / Article (PDF format) Search for the presence of glucocorticoid receptors in dopaminergic neurons of rat ventral tegmenal area and substantia nigra. Anna Czyrak, Agnieszka Chocyk (p. 681) Abstract / Article (PDF format) Conditions of application of repeated transcranial magnetic stimulation to rats may mask the effects of the treatment. Jerzy Michaluk, Lucyna Antkiewicz-Michaluk, Jerzy Vetulani (p. 685) Abstract / Article (PDF format) Influence of new gamma-aminobutyric acid amide derivatives and its phthalimide precursors on the central nervous system activity in mice. Anna Mendyk, Kinga Sałat, Tadeusz Librowski, Ryszard Czarnecki, Barbara Malawska (p. 689) Abstract / Article (PDF format) Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) activate protein kinase C in chick cerebral cortex. Jerzy Z. Nowak, Agnieszka Dejda, Jolanta B. Zawilska (p. 695) Abstract / Article (PDF format) Betahistine inhibits food intake in rats. Adam Szeląg, Małgorzata Trocha, Anna Merwid-Ląd (p. 701) Abstract / Article (PDF format) Influence of thalidomide on Bcl2 expression and proangiogenic cytokine levels in short-term culture of peripheral blood and bone marrow mononuclear cells of multiple myeloma patients. Anna Dmoszyńska, Jacek Roliński, Agnieszka Bojarska-Junak, Joanna Mańko, Dariusz Jawniak, Adam Walter-Croneck, Maria Soroka-Wojtaszko, Marek Hus (p. 709) Abstract / Article (PDF format) Expresion of proenkephalin (PENK) mRNA in inflammatory leukocytes during experimental peritonitis in Swiss mice. Magdalena Chadzinska, Marcin Maj, Anna Scislowska-Czarnecka, Barbara Przewłocka, Barbara Plytycz (p. 715) Abstract / Article (PDF format)