Copyright © 2000 by Institute of Pharmacology
Polish Academy of Sciences 		Pol. J. Pharmacol., 2000, 52, 453-466
ISSN 1230-6002
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PRELIMINARY COMMUNICATION
 ANXIOLYTIC-LIKE EFFECTS OF GROUP I METABOTROPIC GLUTAMATE ANTAGONIST 2-METHYL-6-(PHENYLETHYNYL)-PYRIDINE (MPEP) IN RATS
 Aleksandra Kłodzińska1, Ewa Tatarczyńska1, Ewa Chojnacka-Wójcik1, Andrzej Pilc1,2,#
 1 Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, PL 31-343 Kraków, Poland;
2 Institute of Public Health, Collegium Medicum, Jagiellonian University, Kraków, Poland

Anxiolytic-like effects of group I metabotropic glutamate antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) in rats. A. KŁODZIŃSKA, E. TATARCZYŃSKA, E. CHOJNACKA-WÓJCIK, A. PILC. Pol. J. Pharmacol., 2000, 52, 453-466.

We examined the anxiolytic-like activity of 2-methyl-6-(phenylethynyl)-pyridine (MPEP) using the conflict drinking Vogel test in rats as a model. MPEP is a selective and brain-penetrable mGlu5 receptor antagonist, the most potent compound described so far. The results indicate that MPEP produced a dose-dependent anticonflict effect in rats. These data suggest that selective mGlu5 receptor antagonists may become a new class of anxiolytics.

Key words: mGlu5 receptors, 2-methyl-6-(phenylethynyl)-pyridine, conflict drinking test, anxiety
  # correspondence; e-mail. nfpilc@cyf-kr.edu.pl
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