Copyright © 2000 by Institute of Pharmacology
Polish Academy of Sciences 		Pol. J. Pharmacol., 2000, 52, 459-462
ISSN 1230-6002
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PRELIMINARY COMMUNICATION
 ANXIOLYTIC-LIKE EFFECT OF NAFADOTRIDE AND PNU 99194A, DOPAMINE D3 RECEPTOR ANTAGONISTS, IN ANIMAL MODELS
 Zofia Rogóż1#, Aleksandra Kłodzińska2, Jerzy Maj1
 1 Department of Pharmacology, 2 Department of New Drug Research, Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, PL 31-343 Kraków, Poland

Anxiolytic-like effect of nafadotride and PNU 99194A, dopamine D3 receptor antagonists, in animal models. Z. ROGÓŻ, A. KŁODZIŃSKA, J. MAJ. Pol. J. Pharmacol., 2000, 52, 459-462.

The obtained results indicate that dopamine D3 receptor antagonists, nafadotride and PNU 99194A, produced anxiolytic-like effect in animal models, which suggests a putative role of these drugs in the therapy of anxiety.

Key words: nafadotride, PNU 99194A, conflict drinking test, four-plate test, anxiety, rats, mice
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