Copyright © 2000 by Institute of Pharmacology
Polish Academy of Sciences 		Pol. J. Pharmacol., 2000, 52, 467-471
ISSN 1230-6002
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PRELIMINARY COMMUNICATION
 EFFECTS OF NEUROPEPTIDES OF THE SECRETIN/VIP/PACAP FAMILY ON CYCLIC AMP FORMATION IN THE CHICK HYPOTHALAMUS AND CEREBRAL CORTEX
 Jerzy Z. Nowak1#, Katarzyna Kuba1, Jolanta B. Zawilska1,2
 1 Department of Biogenic Amines, Polish Academy of Sciences, POB-225, Tylna 3, PL 90-950 £ódŸ, Poland,
2 Department of Pharmacodynamics, Medical University of £ódŸ, Poland

Effects of neuropeptides of the secretin/VIP/ PACAP family on cyclic AMP formation in the chick hypothalamus and cerebral cortex. J.Z. NOWAK, K. KUBA, J.B. ZAWILSKA. Pol. J. Pharmacol., 2000, 52, 467-471.

Six neuropeptides: short and long form of the pituitary adenylate cyclase activating polypeptide (PACAP), i.e. PACAP27 and PACAP38, vasoactive intestinal peptide (VIP), peptide histidine-isoleucine (PHI), secretin and glucagon, members of the secretin/VIP/PACAP superfamily of polypeptides, were tested for their ability to stimulate cyclic AMP formation in [3H]adenine-prelabeled slices of the chick hypothalamus and cerebral cortex. Of the tested peptides, only PACAP evoked pronounced and significant responses in the two analyzed brain structures. Although magnitude of the responses varied in different experiments, the effects of both forms of PACAP were usually larger in the cerebral cortex than in the hypothalamus. Glucagon, PHI (both used at concentrations 0.01–1 µM) and VIP (0.1–3 µM) induced concentration-dependent yet comparatively small effects that did not reach statistical significance, while secretin (0.1–3 µM) had no effect.

Key words: neuropeptides, peptide histidine-isoleucine, secretin, glucagon, vasoactive intestinal peptide, pituitary adenylate cyclase-activating polypeptide, cyclic AMP, brain, chicken
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