Pracownicy - Instytut Farmakologii im. Jerzego Maja

Effects of L-DOPA on gene expression in the frontal cortex of rats with unilateral lesions of midbrain dopaminergic neurons. Anna Radlicka, Kinga Kamińska, Malgorzata Borczyk, Marcin Piechota, Michał Korostyński, Joanna Pera, Elżbieta Lorenc-Koci, Jan Rodriguez Parkitna
eNeuro, ENEURO.0234-20.2020 10.1523/ENEURO.0234-20.2020
PMID:33257528

Loss of mu and delta opioid receptors on neurons expressing dopamine receptor D1 has no effect on reward sensitivity. Zofia Harda, Jadwiga Spyrka, Kamila Jastrzębska, Łukasz Szumiec, Anna Bryksa, Marta Klimczak, Maria Polaszek, Sławomir Gołda, Joanna Zajdel, Klaudia Misiołek, Anna Błasiak, Jan Rodriguez Parkitna
Neuropharmacology, S0028-3908(20)30375-0 10.1016/j.neuropharm.2020.108307
PMID:32941853

MicroRNAs are indispensable for the proliferation and differentiation of adult neural progenitor cells in mice. Yang Xu, Karolina Hajdukiewicz, Anshul Tiwari, Joanna Przybyś, Jan Rodriguez Parkitna, Martin Novak, Ilya A Vinnikov, Günther Schütz, Witold Konopka
Biochemical and biophysical research communications, S0006-291X(20)31361-9 10.1016/j.bbrc.2020.06.143
PMID:32828287

Sensitivity to negative and positive feedback as a stable and enduring behavioural trait in rats. Karolina Noworyta-Sokolowska, Anna Kozub, Judyta Jablonska, Jan Rodriguez Parkitna, Robert Drozd, Rafal Rygula
Psychopharmacology, 10.1007/s00213-019-05333-w
PMID:31375849

The Fat Mass and Obesity-Associated Protein (FTO) Regulates Locomotor Responses to Novelty via D2R Medium Spiny Neurons. Johan Ruud, Jens Alber, Anna Tokarska, Linda Engström Ruud, Hendrik Nolte, Nasim Biglari, Rachel Lippert, Änne Lautenschlager, Przemysław E Cieślak, Łukasz Szumiec, Martin E Hess, Hella S Brönneke, Marcus Krüger, Hans Nissbrandt, Tatiana Korotkova, Gilad Silberberg, Jan Rodriguez Parkitna, Jens C Brüning
Cell reports, S2211-1247(19)30657-6 10.1016/j.celrep.2019.05.037
PMID:31189104

Ablation of NMDA receptors in dopamine neurons disrupts attribution of incentive salience to reward-paired stimuli. Przemysław Eligiusz Cieślak, Jan Rodriguez Parkitna
Behavioural brain research, S0166-4328(18)31292-0 10.1016/j.bbr.2019.01.037
PMID:30711444

Antagonism of μ-opioid receptors reduces sensation seeking-like behavior in mice. Magdalena Sikora, Urszula Skupio, Kamila Jastrzebska, Jan Rodriguez Parkitna, Ryszard Przewlocki
Behavioural brain research, S0166-4328(18)31241-5 10.1016/j.bbr.2018.11.039
PMID:30500427

Selective Effects of the Loss of NMDA or mGluR5 Receptors in the Reward System on Adaptive Decision-Making. Przemysław Eligiusz Cieślak, Woo-Young Ahn, Rafał Bogacz, Jan Rodriguez Parkitna
eNeuro, ENEURO.0331-18.2018 10.1523/ENEURO.0331-18.2018
PMID:30302389

Expression of alternatively spliced variants of the Dclk1 gene is regulated by psychotropic drugs. Magdalena Zygmunt, Dżesika Hoinkis, Jacek Hajto, Marcin Piechota, Bożena Skupień-Rabian, Urszula Jankowska, Sylwia Kędracka-Krok, Jan Rodriguez Parkitna, Michał Korostyński
BMC neuroscience, 10.1186/s12868-018-0458-4
PMID:30208879

Decoding the transcriptional programs activated by psychotropic drugs in the brain. Magdalena Zygmunt, Marcin Piechota, Jan Rodriguez Parkitna, Michał Korostyński
Genes, brain, and behavior, 10.1111/gbb.12511
PMID:30084543

Several behavioral traits relevant for alcoholism are controlled by ɣ2 subunit containing GABAAreceptors on dopamine neurons in mice. Andrea Stojakovic, Magdalena Walczak, Przemysław E Cieślak, Aleksandra Trenk, Johan Sköld, Joanna Zajdel, Elahe Mirrasekhian, Camilla Karlsson, Annika Thorsell, Markus Heilig, Jan Rodriguez Parkitna, Tomasz Błasiak, David Engblom
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 10.1038/s41386-018-0022-z
PMID:29463910

The role of NMDA receptor-dependent activity of noradrenergic neurons in attention, impulsivity and exploratory behaviors. P E Cieślak, N Llamosas, T Kos, L Ugedo, K Jastrzębska, M Torrecilla, J Rodriguez Parkitna
Genes, brain, and behavior, 10.1111/gbb.12383
PMID:28383797

Loss of NMDA receptors in dopamine neurons leads to the development of affective disorder-like symptoms in mice. Kamila Jastrzębska, Magdalena Walczak, Przemysław Eligiusz Cieślak, Łukasz Szumiec, Mateusz Turbasa, David Engblom, Tomasz Błasiak, Jan Rodriguez Parkitna
Scientific reports, 10.1038/srep37171
PMID:27853270

Cognitive Judgment Bias Interacts with Risk Based Decision Making and Sensitivity to Dopaminergic Challenge in Male Rats. Robert Drozd, Przemyslaw E Cieslak, Michal Rychlik, Jan Rodriguez Parkitna, Rafal Rygula
Frontiers in behavioral neuroscience, 10.3389/fnbeh.2016.00163
PMID:27601984

NMDA Receptors on Dopaminoceptive Neurons Are Essential for Drug-Induced Conditioned Place Preference. Magdalena Sikora, Krzysztof Tokarski, Bartosz Bobula, Joanna Zajdel, Kamila Jastrzębska, Przemysław Eligiusz Cieślak, Magdalena Zygmunt, Joanna Sowa, Magdalena Smutek, Katarzyna Kamińska, Krystyna Gołembiowska, David Engblom, Grzegorz Hess, Ryszard Przewlocki, Jan Rodriguez Parkitna
eNeuro, 10.1523/ENEURO.0084-15.2016 ENEURO.0084-15.2016
PMID:27294197

Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice. Michael Fritz, Anna M Klawonn, Anna Nilsson, Anand Kumar Singh, Joanna Zajdel, Daniel Björk Wilhelms, Michael Lazarus, Andreas Löfberg, Maarit Jaarola, Unn Örtegren Kugelberg, Timothy R Billiar, David J Hackam, Chhinder P Sodhi, Matthew D Breyer, Johan Jakobsson, Markus Schwaninger, Günther Schütz, Jan Rodriguez Parkitna, Clifford B Saper, Anders Blomqvist, David Engblom
The Journal of clinical investigation,
PMID:26690700

Molecular profile of dissociative drug ketamine in relation to its rapid antidepressant action. Joanna Ficek, Magdalena Zygmunt, Marcin Piechota, Dzesika Hoinkis, Jan Rodriguez Parkitna, Ryszard Przewlocki, Michal Korostynski
BMC genomics, 10.1186/s12864-016-2713-3
PMID:27188165

CREB activity in dopamine D1 receptor expressing neurons regulates cocaine-induced behavioral effects. Ainhoa Bilbao, Claus Rieker, Nazzareno Cannella, Rosanna Parlato, Slawomir Golda, Marcin Piechota, Michal Korostynski, David Engblom, Ryszard Przewlocki, Günther Schütz, Rainer Spanagel, Jan R Parkitna
Frontiers in behavioral neuroscience, 10.3389/fnbeh.2014.00212
PMID:24966820

A model of alcohol drinking under an intermittent access schedule using group-housed mice. Magdalena Smutek, Mateusz Turbasa, Magdalena Sikora, Marcin Piechota, Joanna Zajdel, Ryszard Przewlocki, Jan Rodriguez Parkitna
PloS one, 10.1371/journal.pone.0096787
PMID:24804807

Impaired rRNA synthesis triggers homeostatic responses in hippocampal neurons. Anna Kiryk, Katharina Sowodniok, Grzegorz Kreiner, Jan Rodriguez-Parkitna, Aynur Sönmez, Tomasz Górkiewicz, Holger Bierhoff, Marcin Wawrzyniak, Artur K Janusz, Birgit Liss, Witold Konopka, Günther Schütz, Leszek Kaczmarek, Rosanna Parlato
Frontiers in cellular neuroscience, 10.3389/fncel.2013.00207
PMID:24273493

A neuroprotective phase precedes striatal degeneration upon nucleolar stress. G Kreiner, H Bierhoff, M Armentano, J Rodriguez-Parkitna, K Sowodniok, J R Naranjo, L Bonfanti, B Liss, G Schütz, I Grummt, R Parlato
Cell death and differentiation, 10.1038/cdd.2013.66
PMID:23764776

Novelty-seeking behaviors and the escalation of alcohol drinking after abstinence in mice are controlled by metabotropic glutamate receptor 5 on neurons expressing dopamine d1 receptors. Jan Rodriguez Parkitna, Magdalena Sikora, Sławomir Gołda, Krystyna Gołembiowska, Beata Bystrowska, David Engblom, Ainhoa Bilbao, Ryszard Przewlocki
Biological psychiatry, 10.1016/j.biopsych.2012.07.019 S0006-3223(12)00631-2
PMID:22902169

Glutamate input to noradrenergic neurons plays an essential role in the development of morphine dependence and psychomotor sensitization. Jan Rodriguez Parkitna, Wojciech Solecki, Krystyna Gołembiowska, Krzysztof Tokarski, Jakub Kubik, Sławomir Gołda, Martin Novak, Rosanna Parlato, Grzegorz Hess, Rolf Sprengel, Ryszard Przewłocki
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP), 10.1017/S1461145711001568
PMID:22040728

Addictive drugs and plasticity of glutamatergic synapses on dopaminergic neurons: what have we learned from genetic mouse models? Jan Rodriguez Parkitna, David Engblom
Frontiers in molecular neuroscience, 10.3389/fnmol.2012.00089
PMID:22969704

Ablation of serum response factor in dopaminergic neurons exacerbates susceptibility towards MPTP-induced oxidative stress. Claus Rieker, Andreas Schober, Ainhoa Bilbao, Günther Schütz, Jan Rodriguez Parkitna
The European journal of neuroscience, 10.1111/j.1460-9568.2012.08003.x
PMID:22356487

Glucocorticoid receptor dimerization is required for survival in septic shock via suppression of interleukin-1 in macrophages. Anna Kleiman, Sabine Hübner, Jan M Rodriguez Parkitna, Anita Neumann, Stefan Hofer, Markus A Weigand, Michael Bauer, Wolfgang Schmid, Günter Schütz, Claude Libert, Holger M Reichardt, Jan P Tuckermann
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 10.1096/fj.11-192112
PMID:22042221

Glucocorticoid activity during lung maturation is essential in mesenchymal and less in alveolar epithelial cells. Daniel Habermehl, Jan Rodriguez Parkitna, Sylvia Kaden, Britta Brügger, Felix Wieland, Hermann-Josef Gröne, Günther Schütz
Molecular endocrinology (Baltimore, Md.), 10.1210/me.2009-0380
PMID:21659474

MicroRNA loss enhances learning and memory in mice. Witold Konopka, Anna Kiryk, Martin Novak, Marina Herwerth, Jan Rodriguez Parkitna, Marcin Wawrzyniak, Andreas Kowarsch, Piotr Michaluk, Joanna Dzwonek, Tabea Arnsperger, Grzegorz Wilczynski, Matthias Merkenschlager, Fabian J Theis, Georg Köhr, Leszek Kaczmarek, Günther Schütz
The Journal of neuroscience : the official journal of the Society for Neuroscience, 10.1523/JNEUROSCI.3030-10.2010
PMID:21048142

Effects of the cell type-specific ablation of the cAMP-responsive transcription factor in noradrenergic neurons on locus coeruleus firing and withdrawal behavior after chronic exposure to morphine. Rosanna Parlato, Hans Cruz, Christiane Otto, Patricia Murtra, Jan Rodriguez Parkitna, Miquel Martin, Simona A Bura, Yvonne Begus-Nahrmann, Oliver von Bohlen und Halbach, Rafael Maldonado, Günther Schütz, Christian Lüscher
Journal of neurochemistry, 10.1111/j.1471-4159.2010.06709.x
PMID:20367754

Incentive learning underlying cocaine-seeking requires mGluR5 receptors located on dopamine D1 receptor-expressing neurons. Martin Novak, Briac Halbout, Eoin C O'Connor, Jan Rodriguez Parkitna, Tian Su, Minqiang Chai, Hans S Crombag, Ainhoa Bilbao, Rainer Spanagel, David N Stephens, Günther Schütz, David Engblom
The Journal of neuroscience : the official journal of the Society for Neuroscience, 10.1523/JNEUROSCI.2550-10.2010
PMID:20826661

Loss of the serum response factor in the dopamine system leads to hyperactivity. Jan Rodriguez Parkitna, Ainhoa Bilbao, Claus Rieker, David Engblom, Marcin Piechota, Alfred Nordheim, Rainer Spanagel, Günther Schütz
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 10.1096/fj.09-151423
PMID:20223941

Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc. Manuel Mameli, Briac Halbout, Cyril Creton, David Engblom, Jan Rodriguez Parkitna, Rainer Spanagel, Christian Lüscher
Nature neuroscience, 10.1038/nn.2367
PMID:19597494

Generation of Cre recombinase-expressing transgenic mice using bacterial artificial chromosomes. Jan Rodriguez Parkitna, David Engblom, Günther Schütz
Methods in molecular biology (Clifton, N.J.), 10.1007/978-1-59745-471-1_17
PMID:19266340

Local peripheral opioid effects and expression of opioid genes in the spinal cord and dorsal root ganglia in neuropathic and inflammatory pain. Ilona Obara, Jan Rodriguez Parkitna, Michal Korostynski, Wioletta Makuch, Dorota Kaminska, Barbara Przewlocka, Ryszard Przewlocki
Pain, 10.1016/j.pain.2008.12.006
PMID:19147290

Loss of the Ca2+/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine. Ainhoa Bilbao, Jan Rodriguez Parkitna, David Engblom, Stéphanie Perreau-Lenz, Carles Sanchis-Segura, Miriam Schneider, Witold Konopka, Magdalena Westphal, Gerome Breen, Sylvane Desrivieres, Matthias Klugmann, Camila Guindalini, Homero Vallada, Ronaldo Laranjeira, Fernando Rodriguez de Fonseca, Gunter Schumann, Günther Schütz, Rainer Spanagel
Proceedings of the National Academy of Sciences of the United States of America, 10.1073/pnas.0803959105
PMID:19001277

Glutamate receptors on dopamine neurons control the persistence of cocaine seeking. David Engblom, Ainhoa Bilbao, Carles Sanchis-Segura, Lionel Dahan, Stéphanie Perreau-Lenz, Bénédicte Balland, Jan Rodriguez Parkitna, Rafael Luján, Briac Halbout, Manuel Mameli, Rosanna Parlato, Rolf Sprengel, Christian Lüscher, Günther Schütz, Rainer Spanagel
Neuron, 10.1016/j.neuron.2008.07.010
PMID:18701074

CREB has a context-dependent role in activity-regulated transcription and maintains neuronal cholesterol homeostasis. Thomas Lemberger, Jan Rodriguez Parkitna, Minqiang Chai, Günther Schütz, David Engblom
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 10.1096/fj.08-107888
PMID:18424767

Effects of glycogen synthase kinase 3beta and cyclin-dependent kinase 5 inhibitors on morphine-induced analgesia and tolerance in rats. Jan Rodriguez Parkitna, Ilona Obara, Agnieszka Wawrzczak-Bargiela, Wioletta Makuch, Barbara Przewlocka, Ryszard Przewlocki
The Journal of pharmacology and experimental therapeutics,
PMID:16902054

Comparison of gene expression profiles in neuropathic and inflammatory pain. J Rodriguez Parkitna, M Korostynski, D Kaminska-Chowaniec, I Obara, J Mika, B Przewlocka, R Przewlocki
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society,
PMID:17033093

Effects of morphine on gene expression in the rat amygdala. J M Rodriguez Parkitna, W Bilecki, P Mierzejewski, R Stefanski, A Ligeza, A Bargiela, B Ziolkowska, W Kostowski, R Przewlocki
Journal of neurochemistry,
PMID:15379885

Cloning and sequence analysis of Galleria mellonella juvenile hormone binding protein--a search for ancestors and relatives. Jan M Rodriguez Parkitna, Andrzej Ozyhar, Jacek R Wiśniewski, Marian Kochman
Biological chemistry,
PMID:12437127

Temperature-sensitive ovarian carcinoma cell line (OvBH-1). Julia K Bar, Antonina Harlozinska, Sabine Kartarius, Mathias Montenarh, Ewa Wyrodek, Jan M Rodriguez Parkitna, Marian Kochman, Andrzej Ozyhar
Japanese journal of cancer research : Gann,
PMID:12359050

Juvenile hormone binding protein and transferrin from Galleria mellonella share a similar structural motif. D Krzyzanowska, A Ozyhar, A Lalik, J M Parkitna, J Szkudlarek, K Waśniowska, E Lisowska, M Kochman
Biological chemistry,
PMID:11530933

Immunoaffinity purification of juvenile hormone-binding protein from Galleria mellonella hemolymph. E Wieczorek, J M Parkitna, J Szkudlarek, A Ozyhar, M Kochman
Acta biochimica Polonica,
PMID:9104496

Evidence for glycosylation of the juvenile-hormone-binding protein from Galleria mellonella hemolymph. M Duk, H Krotkiewski, E Forest, J M Rodriguez Parkitna, M Kochman, E Lisowska
European journal of biochemistry / FEBS,
PMID:9022705

Prof. dr hab. Jan Manuel Rodriguez Parkitna

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