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Chronic treatments with haloperidol and clozapine alter the level of NMDA-R1 mRNA in the rat brain: an in situ hybridization study. Krystyna Ossowska, Małgorzata Pietraszek, Jadwiga Wardas, Marta Dziedzicka-Wasylewska, Dorota Nowicka, Stanisław Wolfarth (p. 1) Abstract / Article (PDF format) Effect of (S)-3,5-DHPG on learning, exploratory activity and anxiety in rats with experimental hypoxia. Agnieszka Nadlewska, Halina Car, Robert Oksztel, Konstanty Wiśniewski (p. 11) Abstract / Article (PDF format) Role of noradrenergic system in the mechanism of action of endogenous neurotoxin 1,2,3,4-tetrahydroisoquinoline: biochemical and functional studies. Jerzy Michaluk, Anna Krygowska-Wajs, Beata Karolewicz, Lucyna Antkiewicz-Michaluk (p. 19) Abstract / Article (PDF format) Role of nitric oxide in benzodiazepines-induced antinociception in mice. Sylwia Talarek, Sylwia Fidecka (p. 27) Abstract / Article (PDF format) Effects of tibolone on the development of osteopenia induced by ovariectomy in rats. Maria Pytlik (p. 35) Abstract / Article (PDF format) In vitro cytostatic activity of 8-substituted and tricyclic analogues of acyclovir. Bogusław Hładoń, Tomasz Gośliński, Halina Laskowska, Daniel Baranowski, Tomasz Ostrowski, Joanna Zeidler, Piotr Ruszkowski, Bożenna Golankiewicz (p. 45) Abstract / Article (PDF format) Synthesis, antibacterial, antifungal and genotoxic activity of bis-1,3,4-oxadiazole derivatives. Ahmed O. Maslat, Mahmud Abussaud, Hasan Tashtoush, Mahmoud AL-Talib (p. 55) Abstract / Article (PDF format) SHORT COMMUNICATIONS Prolonged treatment with glucocorticoid dexamethasone suppresses melatonin production by the chick pineal gland and retina. Jolanta B. Zawilska, Magdalena Sadowska (p. 61) Abstract / Article (PDF format) In vitro effects of some anesthetic drugs on enzymatic activity of human red blood cell glucose 6-phosphate dehydrogenase. Sayit Altikat, Mehmet Çiftçi, Mehmet E. Büyükokuroglu (p. 67) Abstract / Article (PDF format) PRELIMINARY COMMUNICATION Inhibition of arachidonic acid cascade attenuates the induction of c-FOS proteins by DOI, 5-HT2A/2C receptor agonist, in the rat cortex. Marzena Maćkowiak, Anna Czyrak, Krzysztof Wędzony (p. 73) Abstract / Article (PDF format) Abstracts of Sixth Conference on PROGRESS IN ETIOPATHOGENESIS OF SEIZURES (p. 77) (PDF format)

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Effect of imipramine on brain D-1 and 5-HT-2A receptors in a chronic unpredictable stress model in rats. Grażyna Ossowska, Gabriel Nowak, Bożena Klenk-Majewska, Zofia Danilczuk, Iwona Żebrowska-Łupina (p. 89) Abstract / Article (PDF format) Behavioral effects of the selective blockade of metabotropic glutamate receptor subtype 5 in experimental hypoxia. Agnieszka Nadlewska, Halina Car, Róża J. Wiśniewska, Konstanty Wiśniewski (p. 95) Abstract / Article (PDF format) Effects of tamoxifen, mifepristone and cyproterone on the electroconvulsive threshold and pentetrazole-induced convulsions in mice. Kinga K. Borowicz, Jarogniew Łuszczki, Mariusz Matuszek, Zdzisław Kleinrok, Stanisław J. Czuczwar (p. 103) Abstract / Article (PDF format) Lack of interaction between the behavioral effects of ketamine and benzodiazepines in mice. Sylwia Fidecka, Ewa Pirogowicz (p. 111) Abstract / Article (PDF format) Adenosine receptor ligands and cocaine in conditioned place preference (CPP) test in rats. Ewa Poleszak, Danuta Malec (p. 119) Abstract / Article (PDF format) Effect of subchronic ethanol treatment on plasma and cerebrospinal fluid leptin levels in rats selectively bred for high and low alcohol preference. Przemysław Mikołajczak, Irena Okulicz-Kozaryn, Ewa Kamińska, Krzysztof Wiktorowicz, Kinga Leśniewska, Wanda Dyr, Wojciech Kostowski (p. 127) Abstract / Article (PDF format) Effects of porcine galanin, galanin(1-15)NH2 and its new analogues on glucose-induced insulin secretion. Jarosław Ruczyński, Magdalena Cybal, Czesław Wójcikowski, Piotr Rekowski (p. 133) Abstract / Article (PDF format) Cerivastatin modulates plasma paraoxonase/arylesterase activity and oxidant-antioxidant balance in the rat. Jerzy Bełtowski, Grażyna Wójcicka, Mariusz Mydlarczyk, Anna Jamroz (p. 143) Abstract / Article (PDF format) Influence of midazolam on pharmacokinetic parameters of procainamide in rabbits. Daria Orszulak-Michalak, Jacek Owczarek, Anna K. Wiktorowska-Owczarek (p. 151) Abstract / Article (PDF format) SHORT COMMUNICATIONS Interactions between human platelets and eosinophils are mediated by selectin-P. Jacek Jawień, Stefan Chłopicki, Ryszard J. Gryglewski (p. 157) Abstract / Article (PDF format) Saliva as an alternative specimen for alcohol determination in the human body. Wojciech Gubała, Dariusz Zuba (p. 161) Abstract / Article (PDF format) Abstracts of the ELEVENTH DAYS of NEUROPSYCHOPHARMACOLOGY (p. 175) Lectures / Oral presentations (PDF format)

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OBITUARY - Professor Stanisław Misztal, Ph.D. (1927–2002). Edmund Przegaliński (p. 211) (PDF format) REVIEW - Beneficial and harmful effects of thiols Lidia Włodek (p. 215) Abstract / Article (PDF format) Neurotransmitter levels and [3H]muscimol binding sites in the brain of rats selectively bred for alcohol preference and non-preference. Wanda Dyr, Marek Siemiątkowski, Paweł Krząścik, Andrzej Bidziński, Adam Płaźnik, Wojciech Kostowski (p. 225) Abstract / Article (PDF format) Effects of alpha-ketoglutarate on lipid peroxidation and antioxidant status during chronic ethanol administration in Wistar rats. Selvaraj Velvizhi, Thiyagarajan Nagalashmi, Mustafa Mohamed Essa, Kadiyala Babu Dakshayani, Perumal Subramanian (p. 231) Abstract / Article (PDF format) Influence of SKF 91488, histamine N-methyltransferase inhibitor, on the central cardiovascular regulation during controlled, stepwise hemorrhagic hypotension in rats. Jerzy Jochem, Krystyna Żwirska-Korczała, Barbara Rybus-Kalinowska, Julia Jagodzińska, Ilona Korzonek-Szlacheta (p. 237) Abstract / Article (PDF format) Central nervous system activity of new pyrimidine-8-on[2,1-f]theophylline-9-alkylcarboxylic acids derivatives. Omeran Fhid, Maciej Pawłowski, Barbara Filipek, Renata Horodyńska, Dorota Maciąg (p. 245) Abstract / Article (PDF format) Effect of nimesulide on the indomethacin- and ibuprofen-induced ulcer in rat gastric tissue. Halis Süleyman, Konca Altynkaynak, Fatma Göçer, Ahmet Maraş, Fatih Akçay, M. Derya Onuk, Akçahan Gepdiremen (p. 255) Abstract / Article (PDF format) Comparison of motor reactivity of the colonic muscularis mucosae isolated from human, guinea pig and rat in vitro. Yuichiro Kamikawa, Asako Shibukawa, Kohsuke Uchida, Atsushi Sakuma, Kei-ichi Kubota, Yasuo Ohno (p. 261) Abstract / Article (PDF format) Effect of capsaicin and dimethyl sulfoxide on ion transport in the selected experimental models. Danuta I. Kosik-Bogacka, Bolesław Banach, Tomasz Tyrakowski, Iwona Wojciechowska (p. 267) Abstract / Article (PDF format) Effects of some drugs on rat erythrocyte 6-phosphogluconate dehydrogenase: an in vitro and in vivo study. Mehmet Çiftçi, Şükrü Beydemir, Hayrullah Yílmaz, Ebubekir Bakan (p. 275) Abstract / Article (PDF format) SHORT COMMUNICATION Homocysteine-induced augmentation of spontaneous contraction of isolated guinea pig myometrium. Ahmet Ayar, Niyazi Tug, Husnu Celik, Mete Ozcan, Oguz Ozcelik (p. 281) Abstract / Article (PDF format) PRELIMINARY COMMUNICATON Prescribing pattern of anti-seizure medications (ASMs): an evaluation of extent of xanthine co-medication. Devi Manjula, Joy David, Chanda Kulkarni (p. 285) Abstract / Article (PDF format)

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REVIEW - Neuronal basis of neuroleptic-induced extrapyramidal side effects. Krystyna Ossowska (p. 299) Abstract / Article (PDF format) REVIEW - Neuroprotective role of adenosine in the CNS. Jadwiga Wardas (p. 313) Abstract / Article (PDF format) In the search for selective ligands of 5-HT5, 5-HT6 and 5-HT7 serotonin receptors. Anna Wesołowska (p. 327) Abstract / Article (PDF format) Effect of antidepressant drugs on the hypothalamic-pituitary-adrenal axis activity and glucocorticoid receptor function. Bogusława Budziszewska (p. 343) Abstract / Article (PDF format) Effect of intra-tegmental microinjections of 5-HT1B receptor ligands on the amphetamine-induced locomotor hyperactivity in rats. Iwona Papla, Małgorzata Filip, Edmund Przegaliński (p. 351) Abstract / Article (PDF format) Cocaine-induced hyperactivity is more influenced by adenosine receptor agonists than amphetamine-induced hyperactivity. Ewa Poleszak, Danuta Malec (p. 359) Abstract / Article (PDF format) Effect of cocaine and amphetamine on biosynthesis of proenkephalin and prodynorphin in some regions of the rat limbic system. Jadwiga Turchan, Marcin Maj, Barbara Przewłocka, Ryszard Przewłocki (p. 367) Abstract / Article (PDF format) Repeated treatment with selective serotonin reuptake inhibitors but not anxiolytics prevents the stress-induced deficit of fighting behavior. Grażyna Ossowska, Iwona Żebrowska-Łupina, Zofia Danilczuk, Bożena Klenk-Majewska (p. 373) Abstract / Article (PDF format) Effect of repeated treatment with mirtazapine on the central dopaminergic D2/D3 receptors. Zofia Rogóż, Andrzej Wróbel, Daniel Dlaboga, Marta Dziedzicka-Wasylewska (p. 381) Abstract / Article (PDF format) Pharmacological analysis of the hypothermic effects of NAN-190 and its analogs, postsynaptic 5-HT1A receptor antagonists, in mice. Anna Wesołowska, Jolanta Borycz, Maria H. Paluchowska, Ewa Chojnacka-Wójcik (p. 391) Abstract / Article (PDF format) PRELIMINARY COMMUNICATIONS Using reverse transcription and a competitive polymerase chain reaction for quantification of alpha1B-adrenoceptor mRNA. Grzegorz Kreiner, Marek Sanak, Agnieszka Zelek-Molik, Irena Nalepa (p. 401) Abstract / Article (PDF format) Perazine as a potent inhibitor of human CYP1A2 but not CYP3A4. Jacek Wójcikowski, Lydiane Pichard-Garcia, Patrick Maurel, Władysława A. Daniel (p. 407) Abstract / Article (PDF format)

CONTENTS (PDF format)

L-AP4, a potent agonist of group III metabotropic glutamate receptor, decreases central action of angiotensin II. Małgorzata Fedosiewicz-Wasiluk, Zdzisław Z. Hoły, Konstanty Wiśniewski (p. 415) Abstract / Article (PDF format) Muscimol changes hypoxia-induced impairment of behavior in rats. Robert Oksztel, Halina Car, Konstanty Wiśniewski (p. 423) Abstract / Article (PDF format) Hypoxic pulmonary vasoconstriction in isolated blood-perfused rat lung; modulation by thromboxane A2, platelet-activating factor, cysteinyl leukotrienes and endothelin-1. Stefan Chłopicki, Joanna B. Bartuś, Ryszard J. Gryglewski (p. 433) Abstract / Article (PDF format) Mechanisms of delayed preconditioning with A1 adenosine receptor activation in porcine coronary smooth muscle cells. Mohammed A. Nayeem, S. Jamal Mustafa (p. 443) Abstract / Article (PDF format) Influence of diethyldithiocarbamate on the activity of ecto-ATPase in lymphocytes of rats: ex vivo studies. Leszek Purzyc, Ireneusz Całkosiński, Dorota Polak-Jonkisz (p. 455) Abstract / Article (PDF format) Effects of combination of cyclosporine with losartan or enalapril on kidney function in uremic rats. Arsalan Azzadin, Jolanta Małyszko, Jacek S. Małyszko, Anna Tankiewicz, Michał Myśliwiec, Włodzimierz Buczko (p. 469) Abstract / Article (PDF format) Effect of capsaicin on ion transport in the caecum of rabbits. Danuta Kosik-Bogacka, Bolesław Banach, Tomasz Tyrakowski (p. 475) Abstract / Article (PDF format) Modulation by cationic amphiphilic drugs of serine base-exchange, phosholipase D and intracellular calcium homeostasis in glioma C6 cells. Marta Bobeszko, Rafał Czajkowski, Magdalena Wójcik, Paweł Sabała, Lingsheng Lei, Irena Nalepa, Jolanta Barańska (p. 483) Abstract / Article (PDF format) Distribution of allelic variants of functional C3435T polymorphism of drug transporter MDR1 gene in a sample of Polish population. Krzysztof Jamroziak, Ewa Balcerczak, Wojciech Młynarski, Marek Mirowski, Tadeusz Robak (p. 495) Abstract / Article (PDF format) Influence of midazolam on pharmacokinetics of verapamil in rabbits. Daria Orszulak-Michalak, Jacek Owczarek, Anna K. Wiktorowska-Owczarek (p. 501) Abstract / Article (PDF format) SHORT COMMUNICATIONS Significant variations of responsiveness of rat gut smooth muscles to glutamate. Dragan R. Milovanovic, Milovan Matovic, Biljana Milicic, Slobodan M. Jankovic (p. 507) Abstract / Article (PDF format) Azathioprine-induced fatal macrocytic anemia in rabbits. Saafan Al-Safi, Bassam Tashtoush, Khalid Abdul-Razzak (p. 513) Abstract / Article (PDF format) PRELIMINARY COMMUNICATIONS SIB 1893 possesses pro- and anticonvulsant activity in the electroshock seizure threshold test in mice. Jarogniew Łuszczki, Kinga K. Borowicz, Stanisław J. Czuczwar (p. 517) Abstract / Article (PDF format) Electroconvulsions elevate the levels of lipid peroxidation products in mice. Radosław Rola, Mariusz Świąder, Stanisław J. Czuczwar (p. 521) Abstract / Article (PDF format) Abstracts of the VIII CONFERENCE on ETHANOL-DRUG INTERACTIONS and PHARMACOLOGICAL TREATMENT of ALCOHOL DEPENDENCE (p. 531) Oral presentations / Poster presentations (PDF format)

CONTENTS (PDF format)

OBITUARY - Professor Zdzisław Kleinrok, D.Sc., M.D., D.H.C. mult. (1928–2002). Marian Wielosz, Iwona Żebrowska-Łupina (p. 553) (PDF format) REVIEW - Neuroprotective effects of antiepileptic drugs. Michał K. Trojnar, Robert Małek, Magdalena Chróścinska, Stanisław Nowak, Barbara Błaszczyk, Stanisław J. Czuczwar (p. 557) Abstract / Article (PDF format) REVIEW - Endogenous risk factors in Parkinson’s disease: dopamine and tetrahydroisoquinolines. Lucyna Antkiewicz-Michaluk (p. 567) Abstract / Article (PDF format) REVIEW - Oxidation of dopamine to aminochrome as a mechanism for neurodegeneration of dopaminergic systems in Parkinson’s disease. Possible neuroprotective role of DT-diaphorase. Rebecca Graumann, Irmgard Paris, Pedro Martinez-Alvarado, Pamela Romanque, Carolina Perez-Pastene, Sergio P. Cardenas, Pablo Marin, Fernando Diaz-Grez, Raul Caviedes, Pablo Caviedes, Juan Segura-Aguilar (p. 573) Abstract / Article (PDF format) REVIEW - On the role of metabotropic glutamate receptors in the mechanisms of action of antidepressants. Agnieszka Pałucha, Andrzej Pilc (p. 581) Abstract / Article (PDF format) REVIEW - Mechanisms contributing to antidepressant zinc actions. Gabriel Nowak, Bernadeta Szewczyk (p. 587) Abstract / Article (PDF format) Effect of repeated treatment with reboxetine on the central alpha1-adrenergic and dopaminergic receptors. Zofia Rogóż, Wojciech Margas, Grażyna Skuza, Joanna Solich, Maciej Kuśmider, Marta Dziedzicka-Wasylewska (p. 593) Abstract / Article (PDF format) Role of neuropeptides in antidepressant and memory improving effects of venlafaxine. Elżbieta Nowakowska, Krzysztof Kus, Teresa Bobkiewicz-Kozłowska, Hanka Hertmanowska (p. 605) Abstract / Article (PDF format) Effects of combined administration of 5-HT1A and/or 5-HT1B receptor antagonists and paroxetine or fluoxetine in the forced swimming test in rats. Ewa Tatarczyńska, Aleksandra Kłodzińska, Ewa Chojnacka-Wójcik (p. 615) Abstract / Article (PDF format) Inhibition of amino acid release by 5-HT1B receptor agonist in the rat prefrontal cortex. Krystyna Gołembiowska, Anna Dziubina (p. 625) Abstract / Article (PDF format) Effect of combined treatment with paroxetine and transcranial magnetic stimulation (TMS) on the mitogen-induced proliferative response of rat lymphocytes. Adam Roman, Jerzy Vetulani, Irena Nalepa (p. 633) Abstract / Article (PDF format) Novel N-{omega-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}pyrid-2(1H)-ones with diversified 5-HT1A receptor activity. Maria H. Paluchowska, Ryszard Bugno, Sijka Charakchieva-Minol, Anna Wesołowska, Ewa Chojnacka-Wójcik (p. 641) Abstract / Article (PDF format) Thioridazine-fluoxetine interaction at the level of the distribution process in vivo. Jacek Wójcikowski, Władysława A. Daniel (p. 647) Abstract / Article (PDF format) TNF-alpha in cerebral cortex and cerebellum is affected by amygdalar kindling but not by stimulation of cerebellum. Leonid S. Godlevsky, Alexei A. Shandra, Andrei A. Oleinik, Rooslan S. Vastyanov, Vladimir V. Kostyushov, Oleg L. Timchishin (p. 655) Abstract / Article (PDF format) Differential effect of 3-hydroxy-3-methylglutarylcoenzyme a reductase inhibitors on plasma paraoxonase 1 activity in the rat. Jerzy Bełtowski, Grażyna Wójcicka, Anna Jamroz (p. 661) Abstract / Article (PDF format) Some drug effects on the activity of erythrocyte hexokinase and glucose 6-phosphate dehydrogenase enzymes in vitro and in vivo. Mehmet Çiftçi, Faruk Şenyayla, Hasan Özdemyr, Mehmet E. Büyükokuroglu (p. 673) Abstract / Article (PDF format) SHORT COMMUNICATIONS Interaction of zinc with antidepressants in the forced swimming test in mice. Bernadeta Szewczyk, Piotr Brański, Joanna M. Wierońska, Agnieszka Pałucha, Andrzej Pilc, Gabriel Nowak (p. 681) Abstract / Article (PDF format) Role of dopamine D3 receptors in controlling the expression of cocaine sensitization in rats. Małgorzata Filip, Iwona Papla, Klaudia Czepiel (p. 687) Abstract / Article (PDF format) Influence of pre- or intraoperational use of tramadol (preemptive or preventive analgesia) on tramadol requirement in the early postoperative period. Jerzy Wordliczek, Marcin Banach, Jarosław Garlicki, Joanna Jakowicka-Wordliczek, Jan Dobrogowski (p. 693) Abstract / Article (PDF format) PRELIMINARY COMMUNICATIONS Effect of combined treatment with selective sigma ligands and amantadine in the forced swimming test in rats. Grażyna Skuza, Zofia Rogóż (p. 699) Abstract / Article (PDF format) Effect of joint administration of imipramine and amantadine on binding of [3H]7-OH-DPAT to dopamine D3 receptors in peripheral blood lymphocytes of the patients with drug-resistant unipolar depression. Marta Dziedzicka-Wasylewska, Zofia Rogóż, Joanna Solich, Dominika Dudek, Andrzej Wróbel, Andrzej Zięba (p. 703) Abstract / Article (PDF format) Anxiolytic- and antidepressant-like effects of group III metabotropic glutamate agonist (1S,3R,4S)-1-aminocyclopentane-1,3,4-tricarboxylic acid (ACPT-I) in rats. Ewa Tatarczyńska, Agnieszka Pałucha, Bernadeta Szewczyk, Ewa Chojnacka-Wójcik, Joanna Wierońska, Andrzej Pilc (p. 707) Abstract / Article (PDF format) Effect of antidepressant drugs on the human corticotropin-releasing-hormone gene promoter activity in neuro-2A cells. Bogusława Budziszewska, Lucylla Jaworska-Feil, Magdalena Tetich, Agnieszka Basta-Kaim, Marta Kubera, Monika Leśkiewicz, Władysław Lasoń (p. 711) Abstract / Article (PDF format) Rapid desensitization of receptors for pituitary adenylate cyclase-activating polypeptide (PACAP) in chick cerebral cortex. Paweł Niewiadomski, Jerzy Z. Nowak, Paulina Sędkowska, Jolanta B. Zawilska (p. 717) Abstract / Article (PDF format) Effect of some iono- and metabotropic glutamatergic ligands on neuropeptide Y immunoreactivity in the rat hippocampus. Maria Śmiałowska, Joanna M. Wierońska, Bernadeta Szewczyk, Ewa Obuchowicz (p. 723) Abstract / Article (PDF format) Neuroprotective effects of estrone on NMDA-induced toxicity in primary cultures of rat cortical neurons are independent of estrogen receptors. Małgorzata Kajta, Władysław Lasoń, Ewa Bień, Michał Marszał (p. 727) Abstract / Article (PDF format) Influence of new gamma-hydroxybutyric acid amide analogues on the central nervous system activity in mice. Kinga Sałat, Anna Mendyk, Tadeusz Librowski, Ryszard Czarnecki, Barbara Malawska (p. 731) Abstract / Article (PDF format) Effect of some antipsychotic drugs on immunoreactivity in C57BL/6 mice. Agnieszka Basta-Kaim, Marta Kubera, Bogusława Budziszewska, Joanna Siwanowicz, Władysław Lasoń (p. 737) Abstract / Article (PDF format)