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Copyright © 2000 by Institute of Pharmacology Polish Academy of Sciences |
Pol. J. Pharmacol., 2000, 52, 313-316 ISSN 1230-6002 |
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Combined treatment with NMDA antagonist, CGP 37849, and sigma receptor agonists, SA4503 or DTG, decreases the neuroleptic-induced catalepsy in rats.
G. SKUZA. Pol. J. Pharmacol., 2000, 52, 313-316. The obtained results indicate that joint administration of CGP 37849, a competitive NMDA receptor antagonist, and SA4503, a sigma1 (sigma1) receptor agonist or DTG, sigma1/2 receptor agonist, evoked anticataleptic effect at doses which were ineffective when each of the compounds was given alone. Key words: CGP 37849, sigma agonists, neuroleptic-induced catalepsy, rat |
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