Copyright © 2000 by Institute of Pharmacology
Polish Academy of Sciences 		Pol. J. Pharmacol., 2000, 52, 317-321
ISSN 1230-6002
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PRELIMINARY COMMUNICATION
 INFLUENCE OF NEW MONOTERPENE HOMOLOGUES OF GABA ON THE CENTRAL NERVOUS SYSTEM ACTIVITY IN MICE
 Tadeusz Librowski#, Ryszard Czarnecki, Anna Mendyk, Magdalena Jastrzębska
 Department of Pharmacodynamics, Medical College, Jagiellonian University, Medyczna 9, PL 30-688 Kraków, Poland

Influence of new monoterpene homologues of GABA on the central nervous system activity in mice. G. SKUZA. Pol. J. Pharmacol., 2000, 52, 317-321.

This behavioral study in mice showed that the monoterpene homologues of GABA (SL-1, SL-2 and SL-3), characterized by low toxicity, induced an increase in spontaneous locomotor activity (SL-2 and SL-3). Moreover, SL-3 shortened hexobarbital-induced sleeping time, and SL-1 showed anticonvulsant activity in pentetrazole-induced seizures.

Key words: GABA analogs, locomotor activity, hexobarbital sleep, pentetrazole seizures, lethality, nootropil, mice
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