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Copyright © 2000 by Institute of Pharmacology Polish Academy of Sciences |
Pol. J. Pharmacol., 2000, 52, 187-193 ISSN 1230-6002 |
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Influence of opioid receptor antagonists on motor-impairing effects of benzodiazepines.
S. FIDECKA, R. LANGWIŃSKI. Pol. J. Pharmacol., 2000, 52, 187-193. The influence of naloxone and naltrexone on the motor-impairing effects of diazepam, chlordiazepoxide, clonazepam and estazolam were studied in the aerial righting reflex test (mice, rats), and the first two drugs were examined in the rota-rod test (mice). Benzodiazepine-induced motor incoordination was significantly decreased by naloxone and naltrexone (4–16 mg/kg) in mice and rats in aerial righting reflex test. The motor-impairing effects of diazepam and chlordiazepoxide observed in rota-rod test were significantly diminished only by naltrexone (8–16 mg/kg). These data seem to confirm some interactions between benzodiazepines and opioid system. Key words: benzodiazepines, motor incoordination, naloxone, naltrexone, mice, rats |
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