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Copyright © 2000 by Institute of Pharmacology Polish Academy of Sciences |
Pol. J. Pharmacol., 2000, 52, 179-185 ISSN 1230-6002 |
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Memantine and ACPC affect conditioned place preference in rats.
J. KOTLIŃSKA, G. BIAŁA. Pol. J. Pharmacol., 2000, 52, 179-185. The influence of uncompetitive NMDA receptor antagonist, 1-amino-3,5-dimethyl-adamantane (memantine) and partial glycineB site agonist, 1-aminocyclopropanecarboxylic acid (ACPC) on cocaine-induced conditioned place preference (CPP) were examined in male Wistar rats. After determination of initial preference, animals were conditioned with cocaine (5 mg/kg, ip) for 3 conditioning trials, alone or in combination with memantine (7.5 mg/kg, ip) or ACPC (50.0 mg/kg, ip). Memantine prevented acquisition and expression of the place preference produced by cocaine, while ACPC prevented only acquisition effect. Neither of the NMDA antagonists displayed any reinforcing properties by itself. Our current data suggest that the NMDA receptor complex may be involved in the rewarding effect of cocaine. Key words: ACPC, memantine, cocaine, place conditioning, rats |
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