Copyright © 2000 by Institute of Pharmacology
Polish Academy of Sciences 		Pol. J. Pharmacol., 2000, 52, 101-105
ISSN 1230-6002
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SHORT COMMUNICATION
 EFFECT OF MONOTERPENE DERIVATIVE KP-19 ON THE PRESSOR ACTIVITY OF CATECHOLAMINES IN RATS
 Tadeusz Librowski1,#, Ryszard Czarnecki1, Magdalena Jastrzębska1, Jacek Sapa2
 1 Department of Pharmacodynamics, 2 Laboratory of Pharmacological Screening, Collegium Medicum, Jagiellonian University, Medyczna 9, PL 30-688 Kraków, Poland

Effect of monoterpene derivative KP-19 on the pressor activity of catecholamines in rats. T. LIBROWSKI, R. CZARNECKI, M. JASTRZĘBSKA, J. SAPA. J. Pharmacol., 2000, 52, 101-105.

The present study investigated the influence of KP-19, the propranolol analogue, bearing natural monoterpene moiety in its structure, on the blood pressure and respiration, the effect on the isolated heart rhythm disturbances induced by occlusion and reperfusion and on the pressor activity of catecholamines in normotensive rats.

Key words: propranolol analog, bicyclic monoterpene structure, antiarrhythmic activity, catecholamines
  # correspondence; e-mail: mflibrow@kinga.cyf-kr.edu.pl
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