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Copyright © 2000 by Institute of Pharmacology Polish Academy of Sciences

Pol. J. Pharmacol., 2000, 52, 47-50 ISSN 1230-6002

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PRELIMINARY COMMUNICATION
SYNTHESIS AND PHARMACOLOGICAL CHARACTERISTICS OF NOVEL (Z)-3-ARYLIDENE-INDOLIN-2(1H)-ONES: PRELIMINARY RESULTS
Maria J. Mokrosz^a,#, Sijka Charakchieva-Minol^a, Aneta Kozioł^a, Aleksandra Kłodzińska^b, Ewa Chojnacka-Wójcik^b
a Department of Medicinal Chemistry, ^b Department of New Drug Research, Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, PL 31-343 Kraków, Poland

Synthesis and pharmacological characteristics of novel (Z)-3-arylidene-indolin-2-(1H)-ones: preliminary results. M.J. MOKROSZ, S. CHARAKCHIEVA-MINOL, A. KOZIOL, A. KŁODZIŃSKA, E. CHOJNACKA-WÓJCIK. Pol. J. Pharmacol., 2000, 52, 47-50. New amide derivatives of 1-(m-chlorophenyl)piperazine, the 5-HT2A antagonists 3-6, with moderate in vitro and in vivo activity were obtained by enlargement of the indolin-2(1H)-one core with 3-arylidene substituents. Key words: (Z)-3-arylidene-indolin-2(1H)-ones, 5-HT2A receptor antagonists

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