Copyright © 2000 by Institute of Pharmacology
Polish Academy of Sciences 		Pol. J. Pharmacol., 2000, 52, 39-46
ISSN 1230-6002
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TOPOLOGICAL POTENTIAL OF ZWITTERION ANALOGUES OF CIMETIDINE AS H2 RECEPTOR ANTAGONISTS
 Vijay K. Agrawala, Shailja Sachana, Padmakar V. Khadikarb,#
 a Department of Chemistry, APS University, Rewa 486 003, India,
b Research Division, Laxmi Pest & Fumigation Pvt. Ltd., 3 Khatipura, Indore 452 007, India

Topological potential of zwitterion analogues of cimetidine as H2 receptor antagonists. V.K. AGRAWAL, S. SACHAN, P.V. KHADIKAR. Pol. J. Pharmacol., 2000, 52, 39-46.

Topological potential of zwitterionic analogues of cimetidine as H2 receptor antagonists have been investigated using a number of topological indices viz. molecular redundancy index (MRI), first order molecular connectivity index (1chiv) and rooted Wiener (Ww) and rooted Szeged (Szw) indices. The multiple regression analysis have indicated that the H2 receptor antagonist activities (–logKB) can be modelled using indicator parameters. Mostsignificant results were obtained when MRI was coupled with Ww as well as the indicator parameters (Ip1 and Ip2).

Key words: zwitterion analogues of cimetidine, histamine H2 receptor antagonists, topological potential, QSAR models
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