Copyright © 2000 by Institute of Pharmacology
Polish Academy of Sciences 		Pol. J. Pharmacol., 2000, 52, 477-480
ISSN 1230-6002
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PRELIMINARY COMMUNICATION
 KYNURENIC ACID DOES NOT PROTECT AGAINST NICOTINE-INDUCED SEIZURES IN MICE
 Jacek Kiœ1, Mirosław Czuczwar1, Elżbieta Zielińska1,2, Iwona Bojar1, Stanisław J. Czuczwar3,4, Waldemar A. Turski1,2,#
 1 Department of Pharmacology and Toxicology, Medical University, Jaczewskiego 8, PL 20-090 Lublin, Poland,
2 Department of Toxicology, Institute of Agricultural Medicine, Jaczewskiego 2 , PL 20-950 Lublin, Poland,
3 Department of Pathophysiology, Medical University, Jaczewskiego 8, PL 20-090 Lublin, Poland,
4 Isotope Laboratory, Institute of Agricultural Medicine, Jaczewskiego 2, PL 20-950 Lublin, Poland

Kynurenic acid does not protect against nicotine-induced seizures in mice. J. KIŒ, M. CZUCZWAR, E. ZIELIŃSKA, I. BOJAR, S.J. CZUCZWAR, W.A. TURSKI. Pol. J. Pharmacol., 2000, 52, 477-480.

Kynurenic acid, an antagonist of glutamatergic ionotropic receptors and alpha7 nicotinic cholinergic receptors failed to affect nicotine-induced convulsions in mice which may indicate that alpha7 nicotinic receptor-mediated events play no role in seizure activity produced by nicotine.

Key words: kynurenic acid, dizocilpine, mecamylamine, nicotine, seizures
  # correspondence; e-mail: andreas@galen.imw.lublin.pl
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