Copyright © 2000 by Institute of Pharmacology
Polish Academy of Sciences 		Pol. J. Pharmacol., 2000, 52, 403-406
ISSN 1230-6002
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PRELIMINARY COMMUNICATION
 ZINC EXHIBITS AN ANTIDEPRESSANT-LIKE EFFECT IN THE FORCED SWIMMING TEST IN MICE
 Bernadeta Kroczka1,#, Andrzej Zięba2, Dominika Dudek2, Andrzej Pilc1,3, Gabriel Nowak1,4
 1 Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, PL 31-343 Kraków, Poland;
2 Department of Psychiatry, 3 Department of Drug Management, 4 Laboratory of Radioligand Research, Collegium Medicum, Jagiellonian University, Kraków, Poland

Zinc exhibits an antidepressant-like effect in the forced swimming test in mice. B. KROCZKA, A. ZIĘBA, D. DUDEK, A. PILC, G. NOWAK. Pol. J. Pharmacol., 2000, 52, 403-406.

The effects of zinc, the NMDA receptor inhibitor, were studied in the forced swimming (Porsolt’s) test in mice. Zinc (ZnSO4) at a dose of 30 mg/kg (but not at a dose of 10 mg/kg), similarly to imipramine (30 mg/kg), reduced the immobility time in that test. Moreover, zinc at both doses reduced the locomotor activity. The obtained results indicate that zinc induces an antidepressant-like effect in the forced swimming test. Since zinc reduces the locomotor activity, this antidepressant-like effect is not related to the alteration of general activity.

Key words: zinc, NMDA receptor, forced swimming test
 # correspondence
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