Copyright © 2000 by Institute of Pharmacology
Polish Academy of Sciences 		Pol. J. Pharmacol., 2000, 52, 283-290
ISSN 1230-6002
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ANTICONVULSANT ACTIVITY OF p-CHLOROPHENYL SUBSTITUTED ARYLSEMICARBAZONES - THE ROLE OF PRIMARY TERMINAL AMINO GROUP
 Surendra N. Pandeya#, Vibha Mishra, Ilangovan Ponnilavarasan, James P. Stables1
 Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi – 221 005, India,
1 Antiepileptic Drug Development (ADD) Programme, Epilepsy Branch, National Institute of Health, Rockville, Maryland, USA

Anticonvulsant activity of p-chlorophenyl substituted arylsemicarbazones – the role of primary terminal amino group. S.N. PANDEYA, V. MISHRA, I. PONNILAVARASAN, J.P. STABLES. Pol. J. Pharmacol., 2000, 52, 283-290.

A series of p-chlorophenyl substituted arylsemicarbazones were synthesized and evaluated for anticonvulsant activity. Most of the compounds provided significant protection against maximal electroshock-induced seizures (MES) at 100 mg/kg after 0.5 h and at 300 mg/kg after 4 h in both MES and pentetrazole-induced (PTZ) seizures. In the strychnine-induced seizures (scSTY), the majority of the compounds showed protection at 30 mg/kg. The compound 2 was active in both MES and PTZ tests. The study has shown that the terminal primary amino group is not necessary for anticonvulsant activity.

Key words: anticonvulsant, p-chlorophenylsemicarbazone, synthesis
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