Copyright © 2000 by Institute of Pharmacology
Polish Academy of Sciences 		Pol. J. Pharmacol., 2000, 52, 237-241
ISSN 1230-6002
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PRELIMINARY COMMUNICATION
 PLASMA LEVELS OF INTERLEUKIN-6, INTERLEUKIN-10, AND INTERLEUKIN-1 RECEPTOR ANTAGONIST IN DEPRESSION: COMPARISON BETWEEN THE ACUTE STATE AND AFTER REMISSION
 Marta Kubera1#, Gunter Kenis2, Eugene Bosmans2, Andrzej Zięba4, Dominika Dudek4, Gabriel Nowak3,5, Michael Maes6,7,8
 1 Department of Endocrinology, Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, PL 31-343 Kraków, Poland; 2 Eurogenetics, Tessenderlo, Belgium; 3 Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, PL 31-343 Kraków, Poland; 4 Department of Psychiatry and 5 Laboratory of Radioligand Research, Collegium Medicum, Jagiellonian University, Kraków, Poland; 6 Department of Psychiatry and Neuropsychology, University of Maastricht, The Netherlands; 7 Clinical Research Center for Mental Health, Antwerp, Belgium; 8 Department of Psychiatry, Vanderbilt University, Nashville, USA

Plasma levels of interleukin-6, interleukin-10, and interleukin-1 receptor antagonist in depression: comparison between the acute state and after remission. M. KUBERA, G. KENIS, E. BOSMANS, A. ZIĘBA, D. DUDEK, G. NOWAK, M. MAES. Pol. J. Pharmacol., 2000, 52, 237-241.

There is now some evidence that major depression is accompanied by an immune response with an increased production of pro-inflammatory cytokines. The aim of the present study was to examine serum level of cytokines: interleukin-6 (IL-6), which is considered pro-inflammatory one and anti-inflammatory cytokines: interleukin 10 (IL-10), and interleukin-1 receptor antagonist (IL-1Ra) in acute clinical state of depression and after 6-week antidepressant treatment. Serum IL-6, IL-10, IL-1Ra levels were higher in the subjects with major depression than in normal controls although these results were not statistically significant. The mean score according to the Hamilton Depression Rating Scale (HDRS) in the patients significantly decreased during the 6 weeks of the study, demonstrating an overall improvement. Successful antidepressant treatment had no significant effect on serum level of this cytokines.

Key words: depression, interleukin-6, interleukin-10, interleukin-1 receptor antagonist, remission
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