Copyright © 2000 by Institute of Pharmacology
Polish Academy of Sciences 		Pol. J. Pharmacol., 2000, 52, 67-70
ISSN 1230-6002
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PERSPECTIVES FOR THE USE OF EXCITATORY AMINO ACID IONOTROPIC RECEPTOR ANTAGONISTS AS ANTIEPILEPTIC DRUGS
 Stanisław J. Czuczwar1,2,#
 1 Department of Pharmacology and Toxicology, Medical University, Jaczewskiego 8, PL 20-090 Lublin and
2 Isotope Laboratory, Institute of Agricultural Medicine, Jaczewskiego 2, PL 20-950 Lublin, Poland

Perspectives for the use of excitatory amino acid ionotropic receptor antagonists as antiepileptic drugs. S.J. CZUCZWAR. Pol. J. Pharmacol., 2000, 52, 67-70.

Numerous antagonists of glutamate, belonging to N-methyl-D-aspartate (NMDA) and non-NMDA receptor antagonists, were demonstrated to display anticonvulsant activity in various models of experimental epilepsy. Also, the glutamate antagonists enhanced the protective activity of conventional antiepileptic drugs against maximal electroshock-induced seizures in mice. However, some combinations of conventional antiepileptics with NMDA receptor antagonists resulted in profound adverse effects. In contrast, the antagonists for the non-NMDA receptor group potentiated the anticonvulsant activity of conventional antiepileptics, with no side-effects being observed. In some cases, the combined treatments were superior to the administration of an antiepileptic drugs alone, as regards adverse effects. In no case, glutamate antagonists affected the plasma levels of antiepileptic drugs. These data seem to indicate that non-NMDA receptor antagonists bear more important clinical potential as adjuvant antiepileptic drugs.

Key words: antiepileptic drugs, glutamate, epilepsy, seizures
  # correspondence; e-mail: czuczwar@galen.imw.lublin.pl
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