Popularization of science
PSYCHOPHARMACOLOGY AND THE SEARCH OF NEW DRUGS - A. Nikiforuk
Besides positive and negative symptoms, cognitive deficits are increasingly recognized as a core feature of schizophrenia. These impairments may appear prior to the onset of psychosis and continue to be present after remission. Importantly, neurocognitive impairment is strongly associated with functional outcomes >>
KETAMINE AND DEPRESSION - M. Korostyński
In clinical trials, the NMDA receptor antagonist ketamine was found to act as an antidepressant with rapid and persisting effects, even in otherwise treatment-refractory cases. Identification of the mechanisms underlying ketamine’s antidepressant action may enable the development of novel drugs, with similar clinical properties but lacking undesirable psychotomimetic effects. >>
GLIAL CELLS AND CHRONIC PAIN - J. Mika et al.
Studies conducted by the International Association for the Study of Pain indicate that every fifth European suffers from chronic pain. The implications of chronic pain include significant deterioration of life quality and even material status, since patients often have to face numerous symptoms which unable basic activities and make daily functioning so difficult. >>
THE TREATMENT OF DIABETIC NEUROPATHY - J. Mika et al.
Diabetes mellitus is one of the civilization diseases with rapidly increasing frequency of occurrence around the world, especially among populations of highly developed countries. In Poland, for example, there are about 2.5 million registered diabetics. Diabetic neuropathy is one of late complications of this disease >>
ANTIVIRALS IN THE MANAGEMENT OF NEUROPATHIC PAIN - J. Mika et al.
Neuropathic pain induced by nervous system damage affects increasing number of patients and significantly decreases the quality of their life. Conventional analgesics, especially opioids, have poor efficiency and produce a plethora of undesired side effects. Therefore, it is important to find a new, effective and long-term therapy suitable for patients suffering from neuropathic pain. >>
CHRONIC PAIN AND GENE EXPRESSION - J. Mika et al.
Studies involving gene expression profiling and mass spectrometry suggest that neuropathic pain is associated with a strong activation of certain neuronal genes, as well as genes associated with immune cell responses including microglial activation. >>