Lectures for the 3rd year PhD students in the cycle "Pharmacology of mental and neurological disorders" (a joint examination with Prof. K. Ossowska lecture on Alzheimer's disease).
This course refers to pathophysiology and pharmacology of Parkinson's disease. The initial portion (Part 1) presents an overview of basic neurobiology of the disease, with an emphasis on recent findings. Topics will include motor and non-motor symptoms, genetic background, suggested mechanisms, including oxidative stress, mitochondrial dysfunction, proteasom dysfunction, involvement of inflammatory processes and new hypotheses such as prion hypothesis of Parkinson's disease. Animal models of the disease will also be discussed. Later lectures (Part 2) will focus on issues related to pharmacotherapy used in the treatment of Parkinson's disease, including symptomatic treatment with classic drugs, such as Lewodopa, dopamine receptor agonists (pramipexole, ropinirole), but also clinical trials involving
new drugs, such as adenosine A2A antagonists and others, as well as Deep Brain
Stimulation (DBS). Moreover, new putative therapies such as gene therapy, cell transplantation, vaccination and recent trends in the development of nanophytobioactive compounds and delivery systems will be also presented.