Alzheimer’s disease: pathomechanisms and therapy

The lecture deals with pathomechanisms and therapy of Alzheimer’s disease. The presence of neuropathological brain alterations i.e. extracellular senile plaques containing aggregates of beta-amyloid and intracellular fibrillar tangles built with MAP-protein tau are described, as well as hypotheses regarding involvement of these proteins in neurodegenerative processes. Currently available symptomatic therapies intended to reverse deficiency of cholinergic neurotransmission [acetylcholine esterase (AChE) inhibitors] and to tune disturbed glutamatergic transmission (memantine) are shown. Moreover, some results of preclinical and/or clinical trials concerning disease-modifying therapies aiming at neurotrophic factor-induced neuroprotection, as well as at prevention of aggregation of pathological proteins or their removal are reported.