Katarzyna Głombik, PhD


Katarzyna Głombik, PhD
Position
Assistant

More publications
  • The impact of maternal diabetes on inflammasome NLRP3 activation in the offspring brain - 2015-02-25 - 2018-08-19
    The aim of the project is to determine potential functional changes in the inflammasome NLRP3, considered to be a sensor of metabolic changes in offspring of dams with experimentally induced  diabetes using organotypic cultures of the hippocampus. It is known that fetal exposure to maternal diabetes can activate inflammatory processes and can increase many times a risk of type 2 diabetes in the offspring. However, the mechanism of these disturbances remains unknown. The most recent reports suggest the role of changes in the inflammasome NLPR3 complex in this mechanism which can lead to aggravation of inflammatory processes and disturbances in glucose metabolism or resistance to insulin, thus predisposing offspring to development of type 2 diabetes. Sparse for now studies underlined the significance of disturbances in homeostasis due to pathological factors, like maternal diabetes, for instance, in the modulation of central nervous system function both in young and adult offspring. The studies within this research project will answer the question whether the function of the inflammasome NLRP3 is disturbed in the hippocampus of young offspring of diabetic dams. Thus, they will elucidate causes of the changed inflammatory activation, which can lead to an increased susceptibility to metabolic disturbances of the brain and type 2 diabetes in adulthood. What is more, they can help to discover a new target for anti-diabetic drugs with anti-inflammatory potential and can contribute to a better understanding of the mechanisms of their action.

  • 2016-05-21

National

  • Katedra Biochemii Klinicznej CM UJ
  • Katedra Farmakologii Collegium Medicum UJ
  • Zakład Farmakologii Doświadczalnej, Uniwersytet Medyczny w Białymstoku

International

  • Spedding Research Solutions SARL