Jakub Staroń, PhD
Position
Non-faculty employee, position funded under a grant
Non-faculty employee, position funded under a grant
Department
Department of Medicinal Chemistry
Department of Medicinal Chemistry
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Lactose esters: synthesis and biotechnological applications.
Jakub Staroń, Janusz M Dąbrowski, Ewelina Cichoń, Maciej Guzik
Critical reviews in biotechnology, 10.1080/07388551.2017.1332571
PMID:28585445 -
Reaction mechanism of sterol hydroxylation by steroid C25 dehydrogenase - Homology model, reactivity and isoenzymatic diversity.
Agnieszka Rugor, Anna Wójcik-Augustyn, Ewa Niedzialkowska, Stefan Mordalski, Jakub Staroń, Andrzej Bojarski, Maciej Szaleniec
Journal of inorganic biochemistry, S0162-0134(17)30009-0 10.1016/j.jinorgbio.2017.04.027
PMID:28482186 -
Low-basicity 5-HT7 Receptor Agonists Synthesized Using the van Leusen Multicomponent Protocol.
Adam S Hogendorf, Agata Hogendorf, Rafał Kurczab, Grzegorz Satała, Tomasz Lenda, Maria Walczak, Gniewomir Latacz, Jadwiga Handzlik, Katarzyna Kieć-Kononowicz, Joanna M Wierońska, Monika Woźniak, Paulina Cieślik, Ryszard Bugno, Jakub Staroń, Andrzej J Bojarski
Scientific reports, 10.1038/s41598-017-00822-4
PMID:28473721 -
Pyrano[2,3,4-cd]indole as a Scaffold for Selective Nonbasic 5-HT6R Ligands.
Jakub Staroń, Stefan Mordalski, Dawid Warszycki, Grzegorz Satała, Adam Hogendorf, Andrzej J Bojarski
ACS medicinal chemistry letters, 10.1021/acsmedchemlett.6b00482
PMID:28435524 -
Encapsulation of curcumin in polyelectrolyte nanocapsules and their neuroprotective activity.
Krzysztof Szczepanowicz, Danuta Jantas, Marek Piotrowski, Jakub Staroń, Monika Leśkiewicz, Magdalena Regulska, Władysław Lasoń, Piotr Warszyński
Nanotechnology, 10.1088/0957-4484/27/35/355101
PMID:27454207
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The role of halogen bonding in interaction of ligands with SERT. - 2017-04-01 - 2019-03-31
The aim of this study is to investigate the role of halogen bonds (XB) in binding ligands to serotonin
transporter (SERT) and their influence on ligand selectivity over other receptors, in particular 5-HT6R and 5-HT7R. The basic scientific question in this project is: “Is it possible to increase ligand affinity to SERT by
careful design and introduction of a halogen bond donor into ligand structure?”. Additional goal is the
verification of hypothesis that appropriate design of a molecule possessing halogen bond donor(s) it is
possible to create polypharmacological molecule with affinity for SERT and/or 5-HT6R, 5-HT7R. 5-HT6R
and 5-HT7R were selected as additional targets as they were recently recognized as a very promising targets
for new antidepressant therapeutics possessing procognitive properties. To the best of our knowledge
substance simultaneously exhibiting affinity for SERT and 5-HT6R has never been reported before.
